[22a-A105-1~11] 12.7 Biomedical Engineering and Biochips

[22a-A105-2] Development of molecularly imprinted polymer nanoparticles for selective detection of biomolecules and its application to electrochemical biosensor

〇(D)Youyuan Man¹, Shoichi Nishitani², Toshiya Sakata¹ (1.Tokyo Univ., 2.California Univ., Berkeley)

Keywords:Molecularly imprinted polymer, Nanoparticles, Biosensor

Molecularly-imprinted polymers (MIPs) have so far exhibited low affinity to the target material (template) due to their heterogeneity, and their performance is expected to be improved for biosensor applications. In this study, a solid-phase approach synthesis method is used to produce MIP nanoparticles (nanoMIPs) with more homogeneous and specific binding sites with high affinity to the template. Specifically, HSA nanoMIPs (HNMs) using serum albumin (HSA) as template are synthesised and their basic properties such as affinity characteristics are investigated. Furthermore, it will be developed as an electrode surface material for biosensors with high selectivity and sensitivity in HSA detection.