[22p-A102-1~17] 2.4 Medical application

▲ [22p-A102-11] Feasibility study of chemical separation technique of medical radioisotope, copper-64 produced by accelerator neutrons.

〇(D)Mary Mikhail¹, Tadahiro Kin¹, Kihara Takahiro¹ (1.Kyushu Univ.)

Keywords:Theranostics, Copper-64

Diagnosis and therapy are two techniques that use medical radioisotopes (RIs) for cancer therapy. Recently, theranostics, a new technical term for a combination of diagnosis and therapy, is a step toward personalized treatment essential for patient selection, reducing side effects, and enhancing therapeutic effects. Moreover, radioimmunotherapy uses mAbs (monoclonal antibodies) as “magic bullets” to deliver the RI to the targeted cancerous cells. Copper-64 is a strong candidate for both techniques. This research work focuses on the separation techniques of copper isotopes to achieve a high purity efficient sample for pre-clinical studies. In this experiment, the ion-exchange chromatography technique is proposed to separate the radioactive copper. The technique was tested by a cold experiment. The ICP-AES data show that by applying this proposed technique, the copper was retained in the column during the separation procedure, and finally, the copper was extracted with no zinc impurities. This technique yields a high purity copper sample obtained in a short experimental time.