[23a-E105-1~11] 12.7 Biomedical Engineering and Biochips

[23a-E105-10] Investigation of microfluidics for a cantilever array biosensor

〇(M1)Yuya Takahashi¹, Kotaro Kamitani¹, Carl Frederik Werner¹, Masayuki Sohgawa², Minoru Noda¹ (1.Kyoto Inst., 2.Niigata Univ.)

Keywords:microfluidics, micro-TAS, biosensor

We have been detecting alpha-synuclein, a biomarker for Parkinson's disease, by converting the morphological change associated with foreign molecule recognition of liposomes from surface stress change to gauge resistance change at the cantilever. In order to array this cantilever sensor, we have introduced a microfluidic device for manipulating the solution on the sensor. In this study, we are investigating the array sensor substrate using this microfluidic device. The sensor is arrayed with 16 cells (4×4). To fabricate the microfluidic device, a mold was formed by a 3D printer, and uncured PDMS was poured into the mold and cured. After understanding the preliminary characteristics of the cantilever sensor itself in relation to the flow rate of the introduced liquid, we will confirm the function of the bioarray sensor by detecting α-synuclein using the liposome-immobilized cantilever array sensor integrated with this microfluidic structure.