3:15 PM - 3:30 PM
[23p-E104-9] Numerical evaluation of experimentally observed DNA dynamics near nanopores of different shapes
Keywords:nanopore, finite element method, electroosmosis
Solid state nanopores are expected to become a DNA sequencing as well as commercial sequencing made of biological nanopores. One of issues would be the DNA dynamics when a DNA molecule enters into a nanopore affected by the nanoscale pore geometry. Negatively charged nanopore wall made of SiN induces fluidic flow by electroosmosis generated by screening cation. The direction is opposite to the DNA motion. The counter flow is likely enhanced by the aspect ratio between wall surface and pore area. Therefore, we intentionally made pores with the shape containing high curvature edges and observed DNA dynamics into these pores. The “sharp-edged” pores provided anisotropic entry paths for DNA translocations. Furthermore, the pores dramatically reduced the probability of DNA clogging. The numerical simulation by a finite element method suggests that the force by osmosis exceeds the electrophoresis near the sharp-edge. Finally, we will discuss the nanopore shapes to control the entry routes of DNA for its sensing.