[17a-A409-1~7] 8.4 Plasma life sciences

[17a-A409-3] Characteristics of hydrogen peroxide permeation through biological membrane by applying electric field

〇Yuta Iwata¹, Kosuke Takami¹, Ippei Yagi¹, Kosuke Tachibana², Akinoro Oda³, Takehiko Sato⁴, Satoshi Uchida¹ (1.Tokyo Metropolitan Univ., 2.Oita Univ., 3.Chiba Inst. Technol., 4.Tohoku Univ.)

Keywords:cell membrane, plasma medicine, molecular dynamics

Recently, stable generation technology of atmospheric pressure low-temperature plasma has been established, and its medical applications are rapidly developing. In plasma medicine, electrical, chemical, and optical effects are intricately involved. However, the balance of influences and interactions among these factors are still unknown. In particular, electrical effects such as electric fields and currents are not well understood. In this paper, the mean force potential (PMF) and membrane permeation coefficient of hydrogen peroxide (H₂O₂) under the application of an electric field are derived from the results of molecular dynamics (MD) simulations of intermolecular interactions, and the effects of electric fields on membrane transport are analyzed.