[17p-E102-1~20] 12.7 Biomedical Engineering and Biochips

△ [17p-E102-3] Characterization of aptamer specific biosensing by differential measurement using aptamer-functionalized optical interferometric sensors

〇Shuta Fukuoka¹, Kazuhiro Takahashi¹, Kazuaki Sawada¹, Toshihiko Noda¹, Yong-Joon Choi¹ (1.Toyohashi Univ.)

Keywords:MEMS biosensor, aptamer, optical interferomentic sensor

This study addressed an aptamer-functionalized MEMS biosensor that uniformizes the charge state of the sensor surface, leading to uniformizing initial membrane shape of the reference and measurement sensors for differential measurement. The aptamer was immobilized on the MEMS sensor and the membrane shape was measured, confirming that the aptamer was successfully uniformized. In addition, it was confirmed that the sensitivity of aptamer-modified sensor was higher than that of the conventional antibody-modified sensor.