[S9-1] Crosstalk between skin microbiome and cutaneous immunity
The skin is the human body’s largest organ and is home to a diverse and complex variety of innate and adaptive immune functions that protect against pathogenic invasion. Recent studies have demonstrated that cutaneous commensal bacteria modulated host immune system. For example, Staphylococcus epidermidis, a skin resident commensal bacterium, has been demonstrated to induce CD8+ T cells which have potential to produce inflammatory cytokines such as interferon-gamma and interleukin-17A. In addition, cutaneous microbiota changes occur in the chronic inflammatory skin disorders, such as atopic dermatitis and psoriasis, and may influence the pathogenesis of skin diseases. In this session, I will review recent findings related to the interactions of skin commensal bacteria with skin homeostasis and discuss the role of the dysbiosis of these bacteria in the pathogenesis of skin diseases. In addition, I will share our current projects about not only bacteria but commensal fungi.