[WS8] 低酸素環境と疾患（がん、感染症）の分子論

[WS8-4] 低酸素休眠抗酸菌の主要タンパク質Mycobacterial DNA-binding protein 1

○西山 晃史¹，古寺 哲幸²，清水 将裕³，Anna Savitskaya¹，Shymaa Enany¹，真柳 浩太⁴，山口 雄大⁵，尾関 百合子¹，立石 善隆¹，松本 壮吉¹ (¹新潟大院・医歯学総合・細菌，²金沢大・ナノ生命科学研，³京都大・複合原子力科学研，⁴九州大・生体防御医学研，⁵大阪市大院・医・分子病態薬理)

Mycobacteria can survive long periods in the host as a dormant state. As for tuberculosis, such latent infection is a major source of infection. Mycobacterial DNA-binding protein 1 (MDP1), which is conserved among all mycobacterial species and essential in slow growers such as Mycobacterium tuberculosis var. tuberculosis, was identified as one of the most abundant proteins in hypoxic dormant mycobacteria, suggesting a significant role in the growth regulation and adaptation. MDP1 is a mycobacterial orthologue of bacterial histone-like protein HU, but possesses eukaryotic histone H1-like intrinsically disordered region (IDR) that is not seen in most of other HUs. We recently showed that MDP1 plays a role in chromosome condensation and suppresses multiple cellular functions such as replication and metabolism in the stationary phase, which is important in the long-term survival of mycobacteria. Interestingly, unlike IDR-deficient general HUs, IDR is required to express such MDP1 functions (e.g., chromosome organization, growth/replication, drug tolerance). These data suggest the pivotal role of mycobacteria-specific IDR in MDP1 functions. Here, we summarize our current findings on unique IDR-dependent functions of MDP1 in mycobacteria including the current update of functional study.