[W2-2] The effect of oral dysbiosis on glucose/lipid metabolism
Periodontitis is a chronic infectious disease and causes endotoxemia. In addition, periodontitis has a possibility to change the gut microbiome. Many studies have demonstrated that systemic health depends on balanced microbial communities. In this session, I explain how periodontitis affects metabolic syndrome, including insulin resistance and obesity. We have focused on the increase of ectopic fat accumulation in the liver and skeletal muscles with alteration of gut microbiome. Gene expression in adipose tissues, an important organ for metabolism, was modified by endotoxemia with Porphyromonas gingivalis. We will establish the evidence that improving oral dysbiosis can prevent dysfunctions of glucose/lipid metabolisms.