Oral Session

Oral Session 1-11A Basic reserch for immunotherapy

Fri. Oct 12, 2018 9:00 AM - 10:00 AM No.11 (Osaka International Convention Center, 10F 1004-5)

Chair: Tatsuo Ichinohe (Department of Hematology and Oncology, Reserch Institute for Radiation Biology and Medicine, Hiroshima University, Japan)

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[OS1-11A-1] Human BM-MSC derived extracellular vesicles modulate hematopoietic cells in GVHD mice

Fujii Sumie^1,2, Yasuo Miura^1,3, Aya Fujishiro^1,4, Takero Shindo², Yutaka Shimazu^2,5, Hideyo Hirai¹, Akifumi Takaori-Kondo², Tatsuo Ichinohe³, Taira Maekawa¹ (1.Dept Trans Med Cell Therapy, Kyoto University Hospital, Kyoto, Japan, 2.Dept Hematology Oncology, Kyoto University, Kyoto, Japan, 3.Dept Hematology Oncology, RIRBM, Hiroshima University, Hiroshima, Japan, 4.Div Gastroenterology Hematology, Shiga University of Medical Science, Shiga, Japan, 5.Dept Hematology, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan)

[OS1-11A-2] Understanding pathophysiology of acute and chronic graft-versus-host disease using humanized mice

Rintaro Ono¹, Takashi Watanabe², Eiryo Kawakami³, Mariko Murasawa¹, Masashi Matsuda⁴, Yuho Najima¹, Yoshiki Mochizuki², Hisahiro Yoshida⁴, Kaoru Sato⁵, Hiromasa Yabe⁵, Shunichi Kato⁵, Yoriko Saito¹, Shultz Leonard D.⁶, Osamu Ohara^2,7, Masayuki Amagai^8,9, Haruhiko Koseki⁴, Fumihiko Ishikawa¹ (1.Laboratory for Human Disease Models, RIKEN IMS, Yokohama, Japan, 2.Laboratory for Integrative Genomics, RIKEN IMS, Yokohama, Japan, 3.Disease Biology group, RIKEN MIH, Yokohama, Japan, 4.Laboratory for Developmental Genetics, RIKEN IMS, Yokohama, Japan, 5.Cell Transplantation and Regenerative Medicine, Tokai University, Isehara, Japan, 6.The Jackson Laboratory, Bar Harbor, ME, 7.Human Genome Research, Kazusa DNA Research Institute, Kisarazu, Japan, 8.Laboratory for Skin Homeostasis, RIKEN IMS, Yokohama, Japan, 9.Dermatology, Keio University, Tokyo, Japan)

[OS1-11A-3] Systemic activation of NRF2 alleviates lethal autoimmune inflammation in scurfy mice

Takuma Suzuki^1,2, Shohei Murakami², Hideo Harigae¹, Hozumi Motohashi² (1.Dept. of Hematol and Rheumatol., Tohoku Univ., Sendai, Japan, 2.Dept. of Gene Exp Reg., IDAC, Tohoku Univ., Sendai, Japan)

[OS1-11A-4] A mouse model of LIG4 syndrome with novel LIG4 mutation

Yusuke Yamashita¹, Shinobu Tamura¹, Yuri Fukuda², Ozasa Toshiya², Nobuo Kanazawa³, Hiroaki Hemmi², Koh-Ichiro Yoshiura⁴, Tsuneyasu Kaisho², Takashi Sonoki¹ (1.Department of Hematology/Oncology, Wakayama Medical University, Wakayama, Japan., 2.Department of Immunology, Institute of Advanced Medicine, Wakayama Medical University, 3.Department of Dermatology, Wakayama Medical University, Wakayama, Japan., 4.Department of Human Genetics, Atomic Bomb Disease Insutitute, Nagasaki University)

[OS1-11A-5] Special AT-rich sequence binding protein 1 is involved in the induction of anergic B cells

Takayuki Ozawa, Takafumi Yokota, Yasuhiro Shingai, Tomoaki Ueda, Yukiko Doi, Hirohiko Shibayama, Yuzuru Kanakura (Department of Hematology and Oncology, Osaka University, Osaka, Japan)

[OS1-11A-6] Tracing of retroviral vector in ADA-SCID patients treated with T cell- and stem cell-gene therapy

Toru Uchiyama¹, Sirirat Takahashi¹, Kaori Edasawa¹, Nobuyuki Watanabe¹, Eiichiro Tamura², Akane Miura¹, Motohiro Kato³, Toshinao Kawai², Makoto Otsu⁴, Tadashi Ariga⁵, Masafumi Onodera¹ (1.Dept. Human Genetics, NCCHD, Tokyo, Japan, 2.Div. Immunol., NCCHD., Tokyo, Japan, 3.Child. Cancer Center, NCCHD., Tokyo, Japan, 4.Cent. Stem Cell Biol. Regen. Med., Univ. Tokyo, Tokyo, Japan, 5.Dept. Pediatr., Hokkaido Univ., Sapporo, Japan)