Oral Session

Oral Session 3-10C MPN: Basic (2)

Sun. Oct 14, 2018 1:50 PM - 2:50 PM No.10 (Osaka International Convention Center, 10F 1009)

Chair: Katsuto Takenaka (Hematology, Clinical Immunology and Infectious Diseases Ehime University Graduate School of Medicine, Japan)

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[OS3-10C-1] Hmga2 promotes the development of MPN/MDS in the absence of Tet2

Jie Bai¹, Takako Yokomizo¹, Sho Kubota¹, Atsushi Iwama², Hironori Harada³, Goro Sashida¹ (1.Transcriptional Regulation in Leukemogenesis, IRCMS, Kumamoto University, 2.Institute of Medical Science, University of Tokyo, 3.Laboratory of Oncology, Tokyo University of Pharmacy and Life Sciences)

[OS3-10C-2] Analysis of myeloproliferative neoplasm hematopoiesis with knock-in mice with Calr mutants

Keiji Minakawa¹, Kouki Ueda^2,3, Osamu Nakajima⁴, Takayuki Ikezoe³, Yasuchika Takeishi⁵, Kazuhiko Ikeda¹ (1.Dept. Blood Transfusion and Transplantation Immunology, Fukushima Medical University, 2.Dept. Cell Biology, Albert Einstein College of Medicine, 3.Dept. Hematology, Fukushima Medical University, 4.Institute for Promotion of Medical Science Research, Yamagata University, 5.Dept.Cardiovascular Medicine, Fukushima Medical University)

[OS3-10C-3] Calcium/calmodulin dependent protein kinase 2 is identified as a therapeutic target of myelofibrosis

Masashi Miyauchi, Kazuki Taoka, Yosuke Masamoto, Sho Yamazaki, Shunya Arai, Mineo Kurokawa (Dept. Hematol. and Oncol, Graduate School of Medicine, Tokyo Univ)

[OS3-10C-4] The cooperation between loss of Pcgf1 and an activating JAK2 mutation in the pathogenesis of MPN

Daisuke Shinoda¹, Yaeko Nakajima-Takagi¹, Motohiko Oshima¹, Atsunori Saraya¹, Goro Sashida², Hironori Harada³, Kazuya Shimoda⁴, Haruhiko Koseki⁵, Atsushi Iwama¹ (1.Department of Cellular and Molecular Medicine, Chiba University, Chiba, Japan, 2.International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan, 3.Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan, 4.Department of Gastroenterology and Hematology, Miyazaki University, Miyazaki, Japan, 5.RIKEN Center for Integrative Medical Sciences, Yokohama, Japan)

[OS3-10C-5] Metformin suppresses expression of lysyl-oxidase levels through inhibition of ER stress in MPN

Megumi Suzuki, Megumi Koshiishi, Ichiro Kamashima, Keita Kirito (Hematology, Yamanashi University, Yamanashi, Japan)

[OS3-10C-6] Homomultimerization of mutant calreticulin is required for MPL-binding and -activation

Marito Araki¹, Yinjie Yang², Misa Imai^2,3, Yoshihisa Mizukami^2,4, Yoshihiko Kihara^2,3, Yoshitaka Sunami², Nami Masubuchi^2,5, Yoko Edahiro², Yumi Hironaka², Satoshi Osaga⁶, Akimichi Ohsaka¹, Norio Komatsu² (1.Dept. Transfus. Med. & Stem Cell Reg., Juntendo Univ., Tokyo, Japan, 2.Dept. Hemat., Juntendo Univ., Tokyo, Japan, 3.Lead. Cent. Dev. Res. Cancer Med., Juntendo Univ., Tokyo, Japan, 4.Cent. Genom. & Regen. Med., Juntendo Univ., Tokyo, Japan, 5.Res. Inst. Disease Old Age, Juntendo Univ., Tokyo, Japan, 6.Clin. Res. Man. Cent., Nagoya City Univ. Hosp., Nagoya, Japan)