Oral Session 1-11C MDS: Basic (1)

[OS1-11C-1] Mutant ASXL1 induces mitochondrial dysregulation and ROS-mediated DNA damage in haematopoietic cells

Takeshi Fujino¹, Susumu Goyama¹, Yuki Sugiura², Daichi Inoue³, Satoshi Yamasaki⁴, Akiko Matsumoto⁴, Naru Sato¹, Hironobu Morinaga⁵, Shiori Shikata¹, Reina Nagase¹, Tomofusa Fukuyama¹, Yosuke Tanaka¹, Shuhei Asada¹, Tsuyoshi Fukushima¹, Hiroaki Honda⁶, Emi Nishimura⁵, Tatsuhiro Shibata⁴, Omar Abdel-Wahab³, Makoto Suematsu², Toshio Kitamura¹ (1.Division of Cellular Therapy, University of Tokyo, Tokyo, Japan, 2.Department of Biochemistry, Keio University, Tokyo, Japan, 3.Memorial Sloan-Kettering Cancer Center, New York, USA, 4.Laboratory of Molecular Medicine, University of Tokyo, Tokyo, Japan, 5.Stem Cell Biology, Tokyo Medical and Dental University, Tokyo, Japan, 6.Human Disease Models, Tokyo Women^'s Medical University, Tokyo, Japan)