Oral Session 3-10B MM: Novel therapeutic approaches

[OS3-10B-2] Bi-allelic loss of FAM46C by CRISPR/CAS9 system enhances myeloma cell growth

Jo Kanasugi¹, Ichiro Hanamura¹, Akinobu Ota², Sivasundaram Karnan², Shohei Mizuno¹, Kaori Uchino¹, Ayano Nakamura¹, Soichi Takasugi¹, Tomohiro Horio¹, Mineaki Goto¹, Mayuko Goto¹, Miyuki Takahashi¹, Hidesuke Yamamoto¹, Masaya Watarai¹, Hidetsugu Mihara¹, Takayuki Nakayama⁴, Hidehumi Kato⁵, Susumu Suzuki³, Yoshihisa Kodera⁶, Yoshitaka Hosokawa², Ryuzo Ueda³, Akiyoshi Takami¹ (1.Division of Hematology, Aichi Medical University, Nagakute, Japan, 2.Department of Biochemistry, Aichi Medical University, Nagakute, Japan, 3.Department of Tumor Immunology, Aichi Medical University, Nagakute, Japan, 4.Central Clinical Laboratory, Aichi Medical University, Nagakute, Japan, 5.Blood Transfusion Department, Aichi Medical University Hospital, Nagakute, Japan, 6.Department of Promotion for Blood and Marrow Transplantation)