Oral Session 3-11A AML: Clinical siginificance of genetic abnormalities

[OS3-11A-1] Identification of recurrent CCND3 mutations in MLL-rearranged acute myeloid leukemia

Hidemasa Matsuo¹, Kenichi Yoshida², Kazutaka Fukumura³, Yusuke Shiozawa⁴, Yasuhito Nannya², June Takeda², Hiroo Ueno², Norio Shiba^5,6, Genki Yamato^5,7, Hiroshi Handa⁸, Yuichiro Ono⁹, Nobuhiro Hiramoto⁹, Takayuki Ishikawa⁹, Kensuke Usuki¹⁰, Ken Ishiyama¹¹, Shuichi Miyawaki¹¹, Hidehiro Itonaga¹², Yasushi Miyazaki¹², Machiko Kawamura¹³, Hiroki Yamaguchi¹⁴, Nobutaka Kiyokawa¹⁵, Daisuke Tomizawa¹⁵, Takashi Taga¹⁶, Akio Tawa¹⁷, Yasuhide Hayashi^5,18, Hiroyuki Mano³, Satoru Miyano¹⁹, Yasuhiko Kamikubo¹, Seishi Ogawa², Souichi Adachi¹ (1.Human Health Sciences, Kyoto Univ., Kyoto, Japan, 2.Pathology and Tumor Biology, Kyoto Univ., Kyoto, Japan, 3.Cellular Signaling, Tokyo Univ., Tokyo, Japan, 4.Pediatrics, Tokyo Univ., Tokyo, Japan, 5.Hematology/Oncology, Gunma Children's Medical Center, Gunma, Japan, 6.Pediatrics, Yokohama City University Hospital, Yokohama, Japan, 7.Pediatrics, Gunma University Graduate School of Medicine, Gunma, Japan, 8.Hematology, Gunma University Graduate School of Medicine, Gunma, Japan, 9.Hematology, Kobe City Medical Center General Hospital, Kobe, Japan, 10.Hematology, NTT Medical Center, Tokyo, Japan, 11.Hematology, Tokyo Metropolitan Ohtsuka Hospital, Tokyo, Japan, 12.Hematology, Nagasaki University, Nagasaki, Japan, 13.Hematology, Saitama Cancer Center, Saitama, Japan, 14.Hematology, Nippon Medical School, Tokyo, Japan, 15.National Research Institute for Child Health and Development, Tokyo, Japan, 16.Pediatrics, Shiga University of Medical Science, Otsu, Japan, 17.Pediatrics, Osaka National Hospital, Osaka, Japan, 18.Japanese Red Cross Gunma Blood Center, Gunma, Japan, 19.Laboratory of DNA Information Analysis, Tokyo Univ., Tokyo, Japan)