Oral Session 3-11C AML: Leukemogenesis

[OS3-11C-4] Dual targeting of IMPDH and Vcam1 as a therapeutic approach for MLL-fusion leukemia

Xiaoxiao Liu¹, Yuki Sugiura², Yasutaka Hayashi¹, Iwamura Hiroyuki³, Saito Motoki⁴, Kinouchi Chieko⁴, Satoshi Yamasaki⁵, Tatsuhiro Shibata⁵, Sasaki Atsuo⁶, Schibler Janet⁷, Mulloy James C.⁷, Hitoshi Takizawa⁸, Toshio Kitamura¹, Susumu Goyama¹ (1.Division of Cell Therapy, IMSUT, Univ. of Tokyo., Tokyo, Japan, 2.Keio University School of Medicine, Department of Biochemistry, Tokyo, Japan, 3.Pharmaceutical Products Division, FUJIFILM Corporation,Tokyo, Japan., 4.Pharmaceutical & Healthcare Research Laboratories, FUJIFILM Corporation, Kanagawa, Japan, 5.Human Genome Center, IMSUT, Univ. of Tokyo, Tokyo, Japan, 6.Department of Internal Medicine, University of Cincinnati, OH, USA, 7.Cincinnati Children's Hospital Medical Center,OH, USA, 8.International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan)