Oral Session 3-5A ALL

[OS3-5A-1] Analysis of features of alterations leading to activate NOTCH1 signaling in pediatric T-ALL

Shunsuke Kimura^1,2, Masafumi Seki¹, Kenichi Yoshida³, Hiroo Ueno³, Yusuke Shiozawa³, Tomoya Isobe¹, Kentaro Ohki⁴, Motohiro Kato⁴, Katsuyoshi Koh⁵, Ryoji Kobayashi⁶, Takao Deguchi⁷, Yoshiko Hashii⁸, Toshihiko Imamura⁹, Atsushi Sato¹⁰, Nobutaka Kiyokawa⁴, Atsushi Manabe¹¹, Keizo Horibe¹², Akira Ohara¹³, Masashi Sanada¹², Masao Kobayashi², Akira Oka¹, Yasuhide Hayashi¹⁴, Satoru Miyano¹⁵, Seishi Ogawa³, Junko Takita¹ (1.Department of Pediatrics, The University of Tokyo, Tokyo, Japan, 2.Department of Pediatrics, Hiroshima University, Hiroshima, Japan, 3.Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan, 4.Pediatric Hematology and Oncology Research, National Research Institute, Tokyo, Japan, 5.Department of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan, 6.Department of Pediatrics, Sapporo Hokuyu Hospital, Sapporo, Japan, 7.Department of Pediatrics, Mie University Hospital, Tsu, Japan, 8.Department of Pediatrics, Osaka University, Suita, Japan, 9.Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan, 10.Department of Hematology and Oncology, Miyagi Children's Hospital, Sendai, Japan, 11.Department of Pediatrics, St. Luke's International Hospital, Tokyo, Japan, 12.Clinical Research Center, National-Hospital Organization Nagoya Medical Center, Nagoya, Japan, 13.Department of Pediatrics, Toho University, Tokyo, Japan, 14.Gunma Children's Medical Center, Maebashi, Japan, 15.Human-Genome-Center Institute of Medical Science, The University of Tokyo)