Kiyomi Morita1,2, Feng Wang3, Katharina Jahn4, Yuanqing Yan5, Robert Durruthy-Durruthy6, Anup Parikh6, Jairo Matthews2, Latasha Little3, Curtis Gumbs3, Jianhua Zhang3, Xingzhi Song3, Erika Thompson7, Keyur Patel8, Carlos Bueso-Ramos8, Courtney Dinardo2, Farhad Ravandi2, Elias Jabbour2, Michael Andreeff2, Jorge Cortes2, Marina Konopleva2, Guillermo Garcia-Manero2, Hagop Kantarjian2, Dennis Eastburn6, P Andrew Futreal3, Niko Beerenwinkel4, Koichi Takahashi2 (1.Department of Hematology and Oncology, The University of Tokyo, 2.Department of Leukemia, MD Anderson Cancer Center, 3.Department of Genomic Medicine, MD Anderson Cancer Center, 4.Swiss Federal Institute of Technology in Zurich, 5.The University of Texas Health Science Center at Houston, 6.Mission Bio, Inc., 7.Department of Genetics, MD Anderson Cancer Center, Houston, 8.Department of Hematopathology, MD Anderson Cancer Center, Houston)
Session information
Oral Session
Oral Session 3-12A Genomic Mutation in AML
Sun. Oct 13, 2019 9:00 AM - 10:00 AM No.12 (Tokyo International Forum, 5F G510)
Chair: Yasuhito Nannya (Kyoto University, Dep. of Pathol and Tumor Biol.)
Yang Zhang1, Fang Wang1, Xue Chen1, Yu Zhang1, Mingyu Wang1, Hong Liu1, Panxiang Cao1, Xiaoli Ma1, Xian Zhang1, Peihua Lu1,2, Hongxing Liu1,2 (1.Pathology & Laboratory Medicine Division, Hebei Yanda Lu Daopei Hospital, Langfang, Hebei, People's Republic of China, 2.Beijing Lu Daopei Institute of Hematology, Beijing, Beijing, People's Republic of China)
Ryosaku Inagaki1,2,3, Masahiro Nakagawa1,2, Yasuhito Nanya1, Xingxing Qi1, Lanying Zhao1, June Takeda1, Akinori Yoda1, Ayana Kon1, Hisashi Tsurumi4, Hideki Makishima1, Seishi Ogawa1,5,6 (1.Department of Pathology and Tumor Biology, Kyoto Univ., Kyoto, Japan, 2.DSK Project, Medical Innovation Center, Kyoto University, Kyoto, Japan, 3.Sumitomo Dainippon Pharma Co., Ltd., Osaka, Japan, 4.Department of Hematology, Gifu Univ., Gifu, Japan, 5.WPI-ASHBi, Kyoto Univ., Kyoto, Japan, 6.Centre for Hematology and Regenerative Medicine, Karolinska Institute, Stockholm, Sweden)
Jo Ishizawa1, Sarah Zarabi2,3, Eric Davis4, Ondrej Halgas2,5, Takenobu Nii1, Yulia Jitkova2, Ran Zhao1, Jonathan Stgermain2, Lauren Heese1, Grace Egan2, Vivian Ruvolo1, Samir Barghout2,3, Yuki Nishida1, Rose Hurren2, Marcela Gronda2, Todd Link6, Keith Wong5, Mark Mabanglo5, Kensuke Kojima1,7, Gautam Borthakur1, Neil Maclean2, Mark Minden2,3, Walid Houry5,8, Hagop Kantarjian1, Martin Stogniew9, Brian Raught2,3, Emil Pai2,3,5,10, Aaron Schimmer2,3, Michael Andreeff1 (1.Dept. of Leukemia, UT MD Anderson, Houston, USA, 2.Princess Margaret Cancer Centre, Toronto, Canada, 3.Dept. Med Biophysics, University of Toronto, Toronto, Canada, 4.Dept. of Leukemia, UT MD Anderson, Houston, USA, 5.Dept. of Biochemistry, University of Toronto, Toronto, Canada, 6.Dept. Genomic Medicine, Houston, USA, 7.Div. Hematorology, Respiratory Medicine, Oncology, Dept. Internal Medicine, Saga, Japan, 8.Dept. Chemistry, University of Toronto, Toronto, Canada, 9.Oncoceutics, Inc., Philadelphia, USA, 10.Dept. Molecular Genetics, University of Toronto, Toronto, Canada)
[OS3-12A-5] Genome-wide CRISPR-Cas9 screen identifies novel therapeutic targets for TP53-mutated AML
Yuichiro Semba1,2, Takuji Yamauchi1,2, Fumihiko Nakao1, Qiuming Yao3, Junpei Nogami1, Matthew Canver3, Luca Pinello4, Daniel Bauer3, Koichi Akashi1,2, Takahiro Maeda1,2 (1.Dep. of Med. and Biosystem. Sci., Kyushu Univ., Fukuoka, Japan, 2.Cell. and Mol. Med., Kyushu Univ. Hosp., Fukuoka, Japan, 3.Hemato. Onco., Boston Child. Hosp., Harvard Med. Sch, Boston, USA, 4.Cent. for Cancer Res., Massachusetts Gen. Hosp., Charlestown, USA)
Masayuki Kanda1, Satoshi Wakita1, Haruka Arai1, Yuho Najima2, Kensuke Usuki3, Toshimitsu Ueki4, Iekuni Oh5, Shinichiro Mori6, Nobuhiko Uoshima7, Yutaka Kobayashi7, Shinichi Kako8, Kenji Tajika9, Katsuhiro Shono10, Kensuke Kayamori11, Masao Hagihara12, Junya Kanda13, Hitoji Uchiyama14, Junya Kuroda15, Naoyuki Uchida16, Yasushi Kubota17, Shinya Kimura17, Saiko Kurosawa18, Nana Nakajima1, Masahiro Sakaguchi1, Kazuhiko Kakihana2, Yoshinobu Kanda5,9, Kazuteru Ohashi2, Takahiro Fukuda18, Hiroki Yamaguchi1, Koichi Inokuchi1 (1.Department of Hematology, Nippon Medical School, Tokyo, Japan, 2.Hematology Division, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan, 3.Department of Hematology, NTT Medical Center Tokyo, Tokyo, Japan, 4.Department of Hematology, Nagano Red Cross Hospital, Nagano, Japan, 5.Division of Hematology, Jichi Medical University, Tochigi, Japan, 6.Hemato-Oncology Department, St Lukes International Hospital, Tokyo, Japan, 7.Department of Hematology, Japanese Red Cross KyotoDaini Hospital, Kyoto, Japan, 8.Hematology Division, Saitama Medical Center, Jichi Medical University, Saitama, Japan, 9.Department of Hematology, Yokohama Minami Kyousai Hospital, Kanagawa, Japan, 10.Department of Hematology, Chiba Aoba Municipal Hospital, Chiba, Japan, 11.Department of Hematology, Chiba University Hospital, Chiba, Japan, 12.Department of Hematology, Eiju General Hopital, Tokyo, Japan, 13.Department of Hematology and Oncology, Kyoto University, Kyoto, Japan, 14.Hematology Division, Japanese Red-Cross Kyoto Daiichi Hospital, Kyoto, Japan, 15.Division of Hematology-and-Oncology, Kyoto Prefectural University of Medicine, Kyoto, Japan, 16.Department of Hematology, Toranomon Hospital, Tokyo, Japan, 17.Division of Hematology, Respiratory and Oncology, Saga University, Saga, Japan, 18.Department of HSCT, National Cancer Center Hospital, Tokyo, Japan)