Oral Session 1-11C AML: Pathophysiology (1)

[OS1-11C-5] CRISPR screen identifies PAICS, a de novo purine synthetic enzyme, as a new target for AML therapy

Takuji Yamauchi^1,2, Kohta Miyawaki¹, Yuichiro Semba¹, Fumihiko Nakao¹, Takeshi Sugio^1,2, Kensuke Sasaki¹, Junpei Nogami¹, Schoonenberg Vivien³, Cole Mitchel³, Trevino Claudio³, Yao Qiuming³, Canver Matthew³, Osborne Simon⁴, Pinello Luca⁵, Taylor Debbie⁴, Bauer Daniel³, Koichi Akashi¹, Takahiro Maeda² (1.Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan, 2.Center for Cellular Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan, 3.Boston Children Hospital/Harvard Medical School, Boston, USA, 4.LifeArc, WC1H 9LT, London, United Kingdom, 5.Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts, USA)