Oral Session 2-13A MDS：Basic (1)

[OS2-13A-6] Mutant ASXL1 activates Akt/mTOR signaling and alters physiological aging of hematopoietic stem cells

Takeshi Fujino¹, Susumu Goyama¹, Yuki Sugiura², Daichi Inoue³, Akiho Tsuchiya¹, Satoshi Yamasaki⁴, Akiko Matsumoto⁴, Naru Sato¹, Shuhei Asada¹, Hironobu Morinaga⁵, Shiori Shikata¹, Reina Nagase¹, Tomofusa Fukuyama¹, Yosuke Tanaka¹, Tsuyoshi Fukushima¹, Reina Takeda¹, Keita Yamamoto¹, Hiroaki Honda⁶, Emi Nishimura⁵, Tatsuhiro Shibata⁴, Omar Abdel-Wahab³, Makoto Suematsu², Toshio Kitamura¹ (1.Division of Cellular Therapy, Tokyo University, Japan, 2.Department of Biochemistry, Keio University, Tokyo, Japan, 3.Memorial Sloan-Kettering Cancer Center, New York, USA, 4.Laboratory of Molecular Medicine, Tokyo University, Tokyo, Japan, 5.Stem Cell Biology, Tokyo Medical and Dental University, Japan, 6.Field of Human Disease Models, Tokyo Women^'s Medical University, Japan)