Oral Session 3-12A Genomic Mutation in AML

[OS3-12A-4] Mitochondrial ClpP-mediated proteolysis induces selective lethality in acute myeloid leukemia

Jo Ishizawa¹, Sarah Zarabi^2,3, Eric Davis⁴, Ondrej Halgas^2,5, Takenobu Nii¹, Yulia Jitkova², Ran Zhao¹, Jonathan Stgermain², Lauren Heese¹, Grace Egan², Vivian Ruvolo¹, Samir Barghout^2,3, Yuki Nishida¹, Rose Hurren², Marcela Gronda², Todd Link⁶, Keith Wong⁵, Mark Mabanglo⁵, Kensuke Kojima^1,7, Gautam Borthakur¹, Neil Maclean², Mark Minden^2,3, Walid Houry^5,8, Hagop Kantarjian¹, Martin Stogniew⁹, Brian Raught^2,3, Emil Pai^2,3,5,10, Aaron Schimmer^2,3, Michael Andreeff¹ (1.Dept. of Leukemia, UT MD Anderson, Houston, USA, 2.Princess Margaret Cancer Centre, Toronto, Canada, 3.Dept. Med Biophysics, University of Toronto, Toronto, Canada, 4.Dept. of Leukemia, UT MD Anderson, Houston, USA, 5.Dept. of Biochemistry, University of Toronto, Toronto, Canada, 6.Dept. Genomic Medicine, Houston, USA, 7.Div. Hematorology, Respiratory Medicine, Oncology, Dept. Internal Medicine, Saga, Japan, 8.Dept. Chemistry, University of Toronto, Toronto, Canada, 9.Oncoceutics, Inc., Philadelphia, USA, 10.Dept. Molecular Genetics, University of Toronto, Toronto, Canada)