[O-3-277] Comparison of 3D ASL and DSC Perfusion MRI in Brain tumor
Purpose: Most common MRI perfusion methods to evaluate brain tumor are Dynamic susceptibility contrast (DSC) perfusion MRI and Arterial spin labelling. Recently DSC Tmax is introduced as an reliable parameter for evaluate cerebral ischemia. The purpose of the study was to compare 3D ASL with DSC perfusion MRI parameters especially including a new transit parameter, ‘Tmax’ in brain tumor.
Materials and met hods: Thirty one (N=31) patients with brain tumor are underwent ASL and DSC-MRI. ASL perfusion imaging was performed on 3D pseudo-continuous arterial spin labelling, relative cerebral blood volume (rCBV), relative cerebral blood flow (rCBF) and and several parameters concerning with transit time including Tmax, MTT are obtained by DSC-MRI.
Results: ASL was modestly correlated with rCBV (r=0.487, P=0.006), rCBF(r=0.482, P=0.006) and Tmax (r=-0.411, P=0.022) in the brain tumor. There was also a moderate correlation between Tmax and MTT in brain tumor (r=0.624, P=0.0001). ASL, rCBF and rCBV are significantly higher in IV grade tumor than in III grade tumor (P=0.003, P=0.009 and P=0.003). ASL is significantly higher in GBM than in PCNSL (P=0.016) and in PCNSL & metastasis (P=0.010).
Conclusion: 3D ASL is correlated with Tmax, but not correlated with MTT, which is different from rCBV and rCBF derived from DSC. Perfusion information in 3D ASL would include vascular transit delay contrary to rCBF and rCBV.
Materials and met hods: Thirty one (N=31) patients with brain tumor are underwent ASL and DSC-MRI. ASL perfusion imaging was performed on 3D pseudo-continuous arterial spin labelling, relative cerebral blood volume (rCBV), relative cerebral blood flow (rCBF) and and several parameters concerning with transit time including Tmax, MTT are obtained by DSC-MRI.
Results: ASL was modestly correlated with rCBV (r=0.487, P=0.006), rCBF(r=0.482, P=0.006) and Tmax (r=-0.411, P=0.022) in the brain tumor. There was also a moderate correlation between Tmax and MTT in brain tumor (r=0.624, P=0.0001). ASL, rCBF and rCBV are significantly higher in IV grade tumor than in III grade tumor (P=0.003, P=0.009 and P=0.003). ASL is significantly higher in GBM than in PCNSL (P=0.016) and in PCNSL & metastasis (P=0.010).
Conclusion: 3D ASL is correlated with Tmax, but not correlated with MTT, which is different from rCBV and rCBF derived from DSC. Perfusion information in 3D ASL would include vascular transit delay contrary to rCBF and rCBV.