JSMRM 2017, the 45th annual meeting of the Japanese Society for Magnetic Resonance in Medicine

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Special Lecture

Special Lecture 5

Sat. Sep 16, 2017 9:30 AM - 10:30 AM Room4 (Tobu HG 4F Shohaku)

Organizer:Kei Yamada(Dept of Radiology, Kyoto Prefectural University of Medicine)

GE Healthcare Japan Cor.

【ねらいと概要（Aims & Scope）】
Precision medicine (PM) is an emerging field where genetic or other biomarker information is used to customise an individual's care based on their genotype and phenotype. The phenotype includes phenomena that can be characterised by imaging derived quantitative biomarkers. These biomarkers can be at the morphological, functional, metabolic, micro-environmental or cellular/molecular level. Recent improvements in MRI hardware and software have enabled the development of new and improved imaging methods that can address the challenges of personalised medicine in the areas of disease prevention, diagnosis and therapy. The contribution of imaging to disease prevention is partially addressed by large scale population based imaging and analysis, such as that undertaken by the UK Biobank, which endeavours to investigate associations between imaging and non-imaging phenotypes and health outcomes. Such approaches require the development of rapid and robust MRI techniques in order to provide high throughput and cost-effective imaging protocols. The potential role of MRI in personalised diagnosis and therapeutic monitoring will be driven by the development of imaging methods at the molecular and metabolic level using techniques such as dynamic contrast enhanced (DCE)-MRI and diffusion-weighted (DW)-MRI as well as using non-proton MR techniques such as 23Na and hyperpolarised 13C. Imaging and MRI in particular is also establishing itself as a vital component of the drug discovery pipeline, particularly in the development of validated surrogate endpoints that can dramatically shorten the timeline for clinical trials. The drive to more advanced quantitative techniques requires MR scientists to be engaged in the development and validation of these methods. This presentation will provide an overview of the techniques currently in use in Cambridge that it is hoped will contribute to the vision of PM using MRI.