6:15 PM - 7:15 PM
[II-JCKEOP01-03] Cardiac function of the fetuses with positive maternal anti-SS-A antibody
Maternal anti SS-A antibody affects to the fetal heart and causes heart block and myocarditis. Detection of the damage to the atrioventricular node is well documented. However, the incidence of the myocardial damage is not well known. Therefore, we investigated the cardiac function in the fetuses with maternal anti SS-A antibody.
Method: This is a retrospective study in single center. We reviewed our clinical record of fetal echocardiography in 5 years from Jan. 2012 to Dec 2016. In this period, 24 cases had fetal echocardiography due to maternal positive anti SS-A antibody without fetal heart block. Of the 24, 18 cases had sequential examination from first trimester. Tei index of the right and left ventricle were measured.
Results: Of the 24, first examination were 18w3d to 38w1d (median 22w0d). During pregnancy, 2 cases (8%) had high Tei index >0.7, and other 10 (42%) had relatively high Tei index >0.6. Of the 12, 6 had Tei index >0.6 also at the latest examination before birth, but, the other had transient elevation. Of the 20 with postnatal data (born at 36w5d to 41w2d, median 39w2d; birth weight of 1918g to 3336g, mean 2778g), no case had clinical symptom of cardiac dysfunction, although one had transient tachypnea, one had small for gestational age, and the other had premature rupture of membrane.
Conclusions: Our data suggest high incidence of abnormal Tei index in the fetuses with maternal anti SS-A antibody. Although the cardiac dysfunction seems to be transient and subclinical in most of the cases, further study with postnatal follow-up are required.
Method: This is a retrospective study in single center. We reviewed our clinical record of fetal echocardiography in 5 years from Jan. 2012 to Dec 2016. In this period, 24 cases had fetal echocardiography due to maternal positive anti SS-A antibody without fetal heart block. Of the 24, 18 cases had sequential examination from first trimester. Tei index of the right and left ventricle were measured.
Results: Of the 24, first examination were 18w3d to 38w1d (median 22w0d). During pregnancy, 2 cases (8%) had high Tei index >0.7, and other 10 (42%) had relatively high Tei index >0.6. Of the 12, 6 had Tei index >0.6 also at the latest examination before birth, but, the other had transient elevation. Of the 20 with postnatal data (born at 36w5d to 41w2d, median 39w2d; birth weight of 1918g to 3336g, mean 2778g), no case had clinical symptom of cardiac dysfunction, although one had transient tachypnea, one had small for gestational age, and the other had premature rupture of membrane.
Conclusions: Our data suggest high incidence of abnormal Tei index in the fetuses with maternal anti SS-A antibody. Although the cardiac dysfunction seems to be transient and subclinical in most of the cases, further study with postnatal follow-up are required.