6:15 PM - 7:15 PM
[II-JCKP2-06] The relationship between children metabolic syndrome and target organ damage of essential hypertension
Objective To study the relationship between metabolic syndrome and target organ damage (TOD) of essential hypertension in children.
Methods 165 children older than 10 years were retrospectively enrolled who were diagnosed as essential hypertension. All children were divided into group with metabolic syndrome (Group A) and group without metabolic syndrome (Group B). All clinical data were collected and analyzed using statistic methods.
Results In all recruited adolescents, 58 patients were diagnosed as metabolic syndrome with the rate of 35.2%. The incidence of target organ damage in Group A was significantly higher than Group B (P<0.01）. The incidence of cardiovascular damage,especially left ventricular hypertrophy (LVH) in Group A was much higher than Group B (P<0.001,P<0.05）. The incidence of target organ damage in patients with impaired glucose tolerance was significantly higher than that of patients without those disorders (P<0.05). In particular, the high incidence of cardiac damage was significantly higher in the former (P<0.001). According to the results of multiple factors Logistic regression analysis, metabolic syndrome and elevated average diastolic pressure were independent risk factors for target organ damage (OR=3.538，OR=1.061).
Conclusions Essential hypertension complicated with metabolic syndrome in children had a much higher incidence of TOD than those without metabolic syndrome，especially cardiovascular damage. The examination of metabolic index is benefit for early diagnosis of target organ damage so as to take effective interference.
Methods 165 children older than 10 years were retrospectively enrolled who were diagnosed as essential hypertension. All children were divided into group with metabolic syndrome (Group A) and group without metabolic syndrome (Group B). All clinical data were collected and analyzed using statistic methods.
Results In all recruited adolescents, 58 patients were diagnosed as metabolic syndrome with the rate of 35.2%. The incidence of target organ damage in Group A was significantly higher than Group B (P<0.01）. The incidence of cardiovascular damage,especially left ventricular hypertrophy (LVH) in Group A was much higher than Group B (P<0.001,P<0.05）. The incidence of target organ damage in patients with impaired glucose tolerance was significantly higher than that of patients without those disorders (P<0.05). In particular, the high incidence of cardiac damage was significantly higher in the former (P<0.001). According to the results of multiple factors Logistic regression analysis, metabolic syndrome and elevated average diastolic pressure were independent risk factors for target organ damage (OR=3.538，OR=1.061).
Conclusions Essential hypertension complicated with metabolic syndrome in children had a much higher incidence of TOD than those without metabolic syndrome，especially cardiovascular damage. The examination of metabolic index is benefit for early diagnosis of target organ damage so as to take effective interference.