6:15 PM - 7:15 PM
[II-JCKP2-08] Changes of content of circulating endothelial cells and endothelial progenitor cells in patients with primary hypertension in peripheral blood
Background The key mechanism of target organ damage (TOD) in primary hypertension is vascular endothelial dysfunction. Circulating endothelial cells (CECs) and endothelial progenitor cell (EPCs) count and function testing was reported a new method for endothelial function and estimation.
Objectives To observe the concentration of CECs ＆ EPCs in children with primary hypertension and their changes before and after the treatment.
Methods 64 cases with primary hypertension and 30 cases of healthy children were enrolled, who were divided into healthy children group (n = 30), pre-hypertension group (PHP) (n = 30), and high blood pressure（HP） group (n = 64). Clinical data were collected and recorded. CECs and EPCs counts were measured by flow cytometry. Data were analysis by software SPSS 19.0.
Result CECs counts in PHP and HP group were higher than that of healthy group (P<0.05), while EPCs was significantly lower (P<0.05). However, there was no significant difference between PHP and HP group（P＞0.05）. Meanwhile, there was no significant difference between stage 1 and 2 （P＞0.05）.CECs counts in children with TOD was significantly higher than those without TOD (P<0.05), while EPCs was significantly lower (P<0.05). After 6-month treatment of diet and exercise, CECs counts in children with TOD was significantly lower than before，while EPCs was not significantly different.
Conclusions There were changes of CECs and EPCs counts in children with primary hypertension, especially in children with TOD. Diet and exercise may be helpful for the improvement of endothelial function.
Objectives To observe the concentration of CECs ＆ EPCs in children with primary hypertension and their changes before and after the treatment.
Methods 64 cases with primary hypertension and 30 cases of healthy children were enrolled, who were divided into healthy children group (n = 30), pre-hypertension group (PHP) (n = 30), and high blood pressure（HP） group (n = 64). Clinical data were collected and recorded. CECs and EPCs counts were measured by flow cytometry. Data were analysis by software SPSS 19.0.
Result CECs counts in PHP and HP group were higher than that of healthy group (P<0.05), while EPCs was significantly lower (P<0.05). However, there was no significant difference between PHP and HP group（P＞0.05）. Meanwhile, there was no significant difference between stage 1 and 2 （P＞0.05）.CECs counts in children with TOD was significantly higher than those without TOD (P<0.05), while EPCs was significantly lower (P<0.05). After 6-month treatment of diet and exercise, CECs counts in children with TOD was significantly lower than before，while EPCs was not significantly different.
Conclusions There were changes of CECs and EPCs counts in children with primary hypertension, especially in children with TOD. Diet and exercise may be helpful for the improvement of endothelial function.