6:15 PM - 7:15 PM
[II-JCKP2-10] Myocardial Perfusion Abnormality by SPECT Imaging Correlates with Systemic Ventricular Property in Adults with Congenital Heart Disease
【Background】 The clinical role of myocardial perfusion imaging by single-photo emission computed tomography (SPECT-MPI) remains unclear in adults with congenital heart disease (ACHD).
【Purpose】 This study was to clarify the clinical significance of SPECT-MPI for evaluating the mechanical function and electrical property of the systemic ventricle (SV) in ACHD patients.
【Methods and Results】 Between August 2014 and February 2016, resting SPECT-MPI was performed in 95 ACHD patients (age: 31±10 years, biventricular physiology (BV) in 69 and Fontan physiology (Fontan) in 26). We developed MPI defect score (%D: %) as an index of severity of the SV myocardial perfusion abnormality and compared the index with plasma levels of high-sensitive troponin T (hsTnT), brain natriuretic peptide (BNP), end-diastolic volume index and ejection fraction of the SV (EF), QRS duration, and peak oxygen uptake (ｐVO2). In all ACHD patients, %D was 8.7±8.4. %D was independently correlated positively with QRS duration (p<0.05) and negatively with EF (p<0.001) and pVO2 (p<0.05), whereas %D was not correlated with hsTnT or BNP. These associations remained significant in both ACHD patients with BV (p<0.05-0.001) and Fontan (p<0.05), except for an association of %D with EF in Fontan.
【Conclusion】 SPECT-PMI has a significant role for providing us vital information on SV myocardial perfusion abnormality which is closely associated with SV mechano-electrical property in ACHD patients regardless of the hemodynamic pathophysiology.
【Purpose】 This study was to clarify the clinical significance of SPECT-MPI for evaluating the mechanical function and electrical property of the systemic ventricle (SV) in ACHD patients.
【Methods and Results】 Between August 2014 and February 2016, resting SPECT-MPI was performed in 95 ACHD patients (age: 31±10 years, biventricular physiology (BV) in 69 and Fontan physiology (Fontan) in 26). We developed MPI defect score (%D: %) as an index of severity of the SV myocardial perfusion abnormality and compared the index with plasma levels of high-sensitive troponin T (hsTnT), brain natriuretic peptide (BNP), end-diastolic volume index and ejection fraction of the SV (EF), QRS duration, and peak oxygen uptake (ｐVO2). In all ACHD patients, %D was 8.7±8.4. %D was independently correlated positively with QRS duration (p<0.05) and negatively with EF (p<0.001) and pVO2 (p<0.05), whereas %D was not correlated with hsTnT or BNP. These associations remained significant in both ACHD patients with BV (p<0.05-0.001) and Fontan (p<0.05), except for an association of %D with EF in Fontan.
【Conclusion】 SPECT-PMI has a significant role for providing us vital information on SV myocardial perfusion abnormality which is closely associated with SV mechano-electrical property in ACHD patients regardless of the hemodynamic pathophysiology.