[I-P24-04] 川崎病の急性期における子供のプロカルシトニン濃度に対する診断時年齢の影響
キーワード：Kawasaki, age, procalcitonin
Background: We speculated that age at diagnosis might have an influence on the serum procalcitonin levels in children in the acute phase of Kawasaki disease(KD). Methods: A total of 90 children were studied, of which 60 children in the acute phase of KD were analyzed as two groups, age at diagnosis at or under 3 months of age and over 3 months to 1 year of age. For the control group, 30 children with febrile diseases were compared with the KD groups. Clinical and echocardiographic data of the two KD groups were also compared.Results and discussion: The mean age of children in both groups were 2.5 months and 7.5 months, respectively. All children in both groups were responsive to intravenous immunoglobulin treatment. The duration of fever before IVIG treatment were similar between both groups. The mean procalcitonin level before treatment of infants under 3 months of age were higher than that of infants over 3 months to 1 year of age. In both groups, there were no children who had significant coronary artery lesions. Receiver operating characteristics curve analysis showed the cutoff value of procalcitonin differentiating children with KD from febrile controls to be higher in infants under 3 months of age compared to children over 3 months to 1 year of age.Conclusions: Due to age at diagnosis, differences in significant cutoff values of procalcitonin in differentiating children with KD from children who have febrile diseases may arise. Age at diagnosis should be taken into account in using procalcitonin as a diagnostic marker of acute phase of KD.