[II-JCK02-2] Epidemiologic trends of Kawasaki disease in South Korea from a nationwide survey
We assessed the epidemiologic trends of Kawasaki disease (KD) in South Korea from the nationwide survey. The average annual incidence of KD in South Korea has been increased but stationary recently. The incidence of acute respiratory virus infections and KD in Korea became significantly lower (about 70% of the overall mean weekly positivity rate for viruses and about 60% of the mean incidence of KD cases by Korea national database) since the emergence of the coronavirus disease 2019 (COVID-19) after nonpharmaceutical interventions such as mandatory mask wearing, school closure, social distancing etc. We think cautiously that triggering of respiratory pathogens (such as virus) may be very important etiology of KD. Male to female ratio (about 1.42:1) and incidence of incomplete KD (about 40%) was relatively stationary. 1st intravenous immunoglobulin (IVIG) non-response rate (12.7%) was also stationary but increased in recent years. Incidence of coronary artery aneurysm (CAA) during recent 3 years (CAA, about 1.7% and giant CAA, about 0.17%) is not decreasing. To decrease the incidence of CAA, treatment modality should be changed especially for possible IVIG resistant KD patients at higher risk.