[III-AEPCYIA-03] Low- versus high-concentration intravenous immunoglobulin for children with Kawasaki disease in the acute phase
キーワード:川崎病, IVIG, 10%製剤
Purpose: Few studies have compared the effects of low-concentration (5%) and high-concentration (10%) intravenous immunoglobulin (IVIG) preparations for patients with Kawasaki disease (KD) in the acute phase. The purpose of this study was to compare outcomes between low-and high-concentration IVIG preparations in children with KD, using a national inpatient database in Japan.Method: We used the Diagnostic Procedure Combination database to identify patients with KD treated with IVIG from April 2012 to March 2020. We identified those receiving high-and low-concentration IVIG preparations as an initial treatment. Propensity score-matched analyses were conducted to compare the outcomes between the 2 groups. Instrumental variable analyses were performed to confirm the results.Result: We identified 48 046 patients with KD and created 4:1 propensity score-matched pairs between the low-and high-concentration IVIG groups. There was a significant difference in the percentage with IVIG resistance between the 2 groups (20.6% vs 24.1%; risk difference, 3.5% [95% confidence interval, 2.3-4.7];P = .001). However, there was no significant difference in CAAs (1.6% vs 1.6%; risk difference,0.013% [95% confidence interval, - 0.34 to 0.37]; P = .953). The instrumental variable analyses showed similar results.Conclusions: The proportion of CAAs did not differ significantly between those receiving low-andhigh-concentration IVIG. To confirm the results of this study, prospective studies adjusting for duration of IVIG administration and duration of observation are needed.