[I-P01-3-07] Assessment of Coronary Artery Echo Brightness in Acute Kawasaki Disease.
Keywords:Kawasaki disease, Coronary artery brightness, New index
[Introduction] In the early acute phase of Kawasaki disease (KD), heightened brightness of the left and right coronary arteries suggests coronary arteritis. However, precise echocardiographic criteria for defining this increased brightness remain unclear.[Subjects and Methods] This study analyzed coronary artery images obtained before initial treatment from 63 KD patients (mean age: 2.8±SD 2.3 years). A region of interest within the coronary artery (indicated by the red square in Figure A) was selected to assess coronary artery brightness (CAB). Three arbitrary points were chosen on the artery wall at the right coronary cusp (Figure B), and the z-score of pixel values within the red square region was calculated. Mean pixel value (R) and various indicators were investigated prior to KD treatment, with results reported as mean ± standard deviation and statistical significance set at p less than 0.05.[Results] Mean pixel values (R) for LMT, LAD, and RCA were 0.68 (0.40), 0.82 (0.52), and 0.78 (0.55), respectively. The maximum mean pixel value (R) in each segment showed significant positive correlations with the conventional maximum coronary artery z-score (Max z score; Figure E) and brain natriuretic peptide (BNP) levels (Figure F). ［Conclusion］ We quantified CAB using echocardiography in KD, revealing its association with various indicators. Our method may offer a novel indicator for KD.