Symposium

Symposium4「Unexpected observation related to transporters found during drug development」

Thu. Nov 12, 2015 9:30 AM - 12:00 PM Room D (2Ｆ Heian)

Organizer・Chair:Ikumi Tamai (Department of Membrane Transport and Biopharmaceutics, Kanazawa University), Chair:Takashi Nozawa (Analysis & Pharmacokinetics Research Labs., Astellas Pharma Inc.)

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[SY-04-01] Transporters: understanding of drug action and its clinical application

^○Naohiko Anzai , Promsuk Jutabha (Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine)

[SY-04-02] Drug-induced changes in serum uric acid level explained by transporters found in clinical studies

^○Yukihiro Chino ¹, Ikumi Tamai ² (1.Pharmacokinetics and Metabolism, Drug Safety and Pharmacokinetics Laboratories, Taisho Pharmaceutical Co.,Ltd., 2.Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Science, Kanazawa University)

[SY-04-03] Mechanism of renal toxicity observed in only male mice administered high doses of empagliflozin, an SGLT2 inhibitor 1)

^○Naoki Ishiguro (Pharmacokinetics and Non-Clinical Safety Dept., Kobe Pharm Research Institute, Nippon Boehringer Ingelheim Co.,Ltd.)

[SY-04-04] Is mild serum creatinine elevation a sign of transporter-mediated drug interactions?

^○Hiroyuki Kusuahra (Graduate school of Pharmaceutical Sciences, The University of Tokyo)

[SY-04-05] Approach of PET imaging to Proof of Mechanism study : Anticancer drug accumulation allows in vivo imaging via the transporters in tumor microenvironment

^○Sosuke Miyoshi (Bio-imaging, Translational Science Research Labs, Drug Discovery Research, Astellas Pharma Inc.)