Crystallographic Binding Poses and Metabolites of Antipsychotic Thioridazine with Cytochrome P450 2D6; LC-UV-MS/MS Analysis, Molecular Dynamics and Density Functional Calculations

Katsunori Sasahara

Presentation information

Oral Presentation

5．Phase I enzyme・Regulation

Fri. Nov 13, 2015 4:00 PM - 5:10 PM Room F (2Ｆ Hourai)

Chair:Teruko Imai (Faculty of Pharmaceutical Sciences, Kumamoto University), Masahiro Hiratsuka (Laboratory of Pharmacotherapy of Life-Style Related Diseases, Graduate School of Pharmaceutical Sciences, Tohoku University), Kiyoshi Nagata (Department of Environmental and Health Science Tohoku Pharmaceutical University), Takeo Nakanishi (Faculty of Pharmaceutical Sciences, Kanazawa University)

[O5-1] Crystallographic Binding Poses and Metabolites of Antipsychotic Thioridazine with Cytochrome P450 2D6; LC-UV-MS/MS Analysis, Molecular Dynamics and Density Functional Calculations

^○Katsunori Sasahara ^1,2, Akira Mashima ¹, Tatsusada Yoshida ¹, Hiroshi Chuman ¹ (1.Institute of Biomedical Sciences, Tokushima University Graduate School, 2.Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.)

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