A novel model considering a change in medium unbound fraction caused by a significant ligand-transporter binding can feasibly explain the "albumin-mediated hepatic uptake" phenomenon

Seiji Miyauchi

Presentation information

Oral Presentation

8．Transporter 2

Sat. Nov 14, 2015 2:50 PM - 4:15 PM Room E (2Ｆ Zuiun)

Chair:Yukio Kato (Department of Molecular Pharmacotherapeutics, Faculty of Pharmacy, Kanazawa University), Hiroshi Mizuuchi (DMPK Research Laboratories Mitsubishi Tanabe Pharma Corporation), Hiroaki Yuasa (Graduate School of Pharmaceutical Science, Nagoya City University), Ken-ichi Hosoya (Graduate School of Medicine and Pharmaceutical Sciences University of Toyama)

[O8-1] A novel model considering a change in medium unbound fraction caused by a significant ligand-transporter binding can feasibly explain the "albumin-mediated hepatic uptake" phenomenon

^○Seiji Miyauchi ¹, Masayuki Masuda ¹, Yuudai Tanaka ¹, Shouko Iwakado ¹, Kazumi Shimono ², Soo-Jin Kim ², Yuichi Sugiyama ² (1.Faculty of Pharmaceutical Sciences, Toho University, 2.RIKEN Research Cluster for Innovation, RIKEN)

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