Comparative Evaluation of Unbound Intracellular-Medium (Plasma) Concentration Ratios (Kp,uu) of Poorly-Metabolized Anionic Drugs Using Rat and Human Hepatocytes

Tomohisa Nakada

Presentation information

Oral Presentation

8．Transporter 2

Sat. Nov 14, 2015 2:50 PM - 4:15 PM Room E (2Ｆ Zuiun)

Chair:Yukio Kato (Department of Molecular Pharmacotherapeutics, Faculty of Pharmacy, Kanazawa University), Hiroshi Mizuuchi (DMPK Research Laboratories Mitsubishi Tanabe Pharma Corporation), Hiroaki Yuasa (Graduate School of Pharmaceutical Science, Nagoya City University), Ken-ichi Hosoya (Graduate School of Medicine and Pharmaceutical Sciences University of Toyama)

[O8-7] Comparative Evaluation of Unbound Intracellular-Medium (Plasma) Concentration Ratios (Kp,uu) of Poorly-Metabolized Anionic Drugs Using Rat and Human Hepatocytes

^○Tomohisa Nakada ¹, Kazuaki Ikejiri ², Kota Toshimoto ³, Kei Ogawa ¹, Noriko Hisanaga ¹, Hiroyuki Kusuhara ², Kazuya Maeda ², Yuichi Sugiyama ³ (1.DMPK Research Laboratories, Mitsubishi Tanabe Pharma Corporation, 2.Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 3.Sugiyama Laboratory, RIKEN Innovation Center, Research Cluster for Innovation, RIKEN)

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