31th JSSX Annual Meeting in Matsumoto The Japanese Society for the Study of Xenobiotics

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Oral Presentation

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Thu. Oct 13, 2016 9:00 AM - 10:12 AM Room 5 (The first meeting room)

Seiji Miyauchi (Toho University, Faculty of Pharmaceutical Sciences, Department of Pharmacokinetics), Takeshi Hirota (Department of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University), Takuo Ogihara (Laboratory of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Takasaki University of Health and Welfare), Takuya Fujita (Department of Molecular Pharmacokinetics, College of Pharmaceutical Sciences, Ritsumeikan University), )

[O1-6] In vitro estimation of unbound hepatocyte-to-medium concentration ratios (K p,uu) of statins considering the membrane potential-dependent passive diffusion

Takashi Yoshikado 1, Kota Toshimoto 1, Tomohisa Nakada 2, Kazuaki Ikejiri 3, Kei Ogawa 2, Noriko Hisanaga 2, Hiroyuki Kusuhara 3, Kazuya Maeda 3, Yuichi Sugiyama 1 (1.Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, 2.DMPK Research Laboratories, Mitsubishi Tanabe Pharma Corporation, 3.Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, the University of Tokyo)

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