[O2-4] SARS2-5

[O2-4-17] Metalloproteinase-dependent and TMPRSS2-independent cell surface entry of SARS-CoV-2 requires the furin-cleavage site and the S2 domain of spike protein

*Mizuki Yamamoto¹, Jin Gohda¹, Ayako Kobayashi¹, Keiko Tomita¹, Youko Hirayama¹, Naohiko Koshikawa², Motoharu Seiki³, Kentaro Semba⁴, Tetsu Akiyama⁵, Yasushi Kawaguchi⁶, Jun-ichiro Inoue⁷ (1. Research Center for Asian Infectious Diseases, The Institute of Medical Science, The University of Tokyo, 2. Department of Life Science and Technology, Tokyo Institute of Technology, 3. Division of Cancer Cell Research, The Institute of Medical Science, The University of Tokyo, 4. Department of Life Science and Medical Bio-Science, Waseda University, 5. Laboratory of Molecular and Genetic Information, Institute for Quantitative Biosciences, The University of Tokyo, 6. Division of Molecular Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, 7. Research Platform Office, The Institute of Medical Science, The University of Tokyo)