開催趣旨
Microbiome in Health and Disease
第51回内藤コンファレンス 組織委員長
竹 田 潔
大阪大学大学院医学系研究科 教授
竹 田 潔
大阪大学大学院医学系研究科 教授
長年その実態が不明であった消化管に生息する共生細菌（マイクロバイオーム）が、次世代シークエンサーの開発や培養技術などの革新により明らかになってきた。腸内には、数にして10兆個を超え、種類にして1,000種を超える細菌が共生している。共生細菌（マイクロバイオーム）は腸内に生息するだけでなく、皮膚などの様々な組織にも生息していることが明らかになってきた。これらの共生細菌は、異物を非自己として認識し排除する免疫系にとっては、非自己そのものであるが、免疫による認識・排除が行われることはなく、我々と共生している。そして、これらの共生細菌が我々の健康維持にきわめて重要な役割を担っていることが明らかになってきている。さらには、共生する細菌のバランスが異常になることが、様々な疾患の発症や病態と深く関わることが明らかになってきた。共生細菌（マイクロバイオーム）の急速な理解は、細菌学、免疫学、情報科学、代謝学、臨床医学など様々な研究分野の先端研究者がそれぞれの専門知識・技術を駆使して解析が行われてきたことで進められてきている。今回の内藤コンファレンスでは、マイクロバイオーム研究に携わる様々な研究分野の最前線で活躍する研究者を国内外からお呼びしご講演いただくとともに、公募により参加する若手研究者のポスター発表も実施する。これにより、最先端のマイクロバイオーム研究の動向を知るとともに、参加者の相互交流によりマイクロバイオーム研究領域の次世代研究者の育成も図る。
The symbiotic bacteria (microbiome) that inhabit the gastrointestinal tract have long been unknown, but thanks to innovations in next-generation sequencing and culture technologies, their real nature has become clear these years. In the intestines, there are more than 10 trillion bacteria and more than 1,000 species of bacteria living in symbiosis. It has become clear that symbiotic bacteria (microbiome) not only live in the gut, but also in various tissues, such as the skin. These symbiotic bacteria are non-self to the immune system, which recognizes and eliminates foreign substances as non-self, but they coexist in the body without being recognized and eliminated by the immune system. It has become clear that these symbiotic bacteria play an important role in maintaining our health. It has also become clear that a disturbed balance of microbiome is related to the onset and pathology of various diseases. The rapid understanding of the symbiotic bacteria (microbiome) has been achieved by the analysis of scientists in various research fields such as bacteriology, immunology, informatics, metabolism, and clinical medicine, using their expertise and techniques. At Naito Conference this time, we will invite top scientists from all over the world who are at the forefront of various research fields involved in microbiome research to give lectures, as well as poster presentations by young researchers who will participate in the conference through an open call. This will allow participants to learn about the latest trends in microbiome research and foster the next generation of researchers in the field of microbiome research through mutual exchanges.
The symbiotic bacteria (microbiome) that inhabit the gastrointestinal tract have long been unknown, but thanks to innovations in next-generation sequencing and culture technologies, their real nature has become clear these years. In the intestines, there are more than 10 trillion bacteria and more than 1,000 species of bacteria living in symbiosis. It has become clear that symbiotic bacteria (microbiome) not only live in the gut, but also in various tissues, such as the skin. These symbiotic bacteria are non-self to the immune system, which recognizes and eliminates foreign substances as non-self, but they coexist in the body without being recognized and eliminated by the immune system. It has become clear that these symbiotic bacteria play an important role in maintaining our health. It has also become clear that a disturbed balance of microbiome is related to the onset and pathology of various diseases. The rapid understanding of the symbiotic bacteria (microbiome) has been achieved by the analysis of scientists in various research fields such as bacteriology, immunology, informatics, metabolism, and clinical medicine, using their expertise and techniques. At Naito Conference this time, we will invite top scientists from all over the world who are at the forefront of various research fields involved in microbiome research to give lectures, as well as poster presentations by young researchers who will participate in the conference through an open call. This will allow participants to learn about the latest trends in microbiome research and foster the next generation of researchers in the field of microbiome research through mutual exchanges.