2018年5月23日(水) 09:50 〜 11:50 第9会場 (ロイトン札幌2F リージェント・ホール)

座長：長谷川 隆文（東北大学大学院医学系研究科神経・感覚器病態学講座神経内科学分野）, 福田 光則（東北大学大学院生命科学研究科）

Selective neuronal loss accompanied by specific protein aggregation is the histopathological hallmark of neurodegenerative diseases. Although the abnormal proteins responsible for each disease are different in structure and function, all neurodegenerative disorders share the common process of protein misfolding and aggregation. These aggregates directly and indirectly attack cellular components, leading to neuronal cell death. In order to fight against these continuous threats, cells have evolved ingenious quality control mechanisms that act either to facilitate refolding of misfolded proteins by molecular chaperones or to remove them by proteolytic degradation machinery, including the ubiquitin-proteasome system and autophagy-lysosome pathway. This symposium will facilitate the understanding of the roles of quality control machineries in neurodegenerative diseases and offer helpful hints on how to develop therapeutic strategies to combat these devastating diseases.