Neuroscience Frontier Symposium
Thu. May 24, 2018 3:20 PM - 5:20 PM Room 2 (Sapporo Geibunkan / Zuisetsu （3F）)
Chair: Hideki Mochizuki(Department of Neurology, Osaka University, Japan), Takahiko Tokuda(Department of Molecular Pathobiology of Brain Diseases, Kyoto Prefectural University of Mdecine, Japan)
The Braak’s Staging of PD brain pathology provides useful information about staged distribution of Lewy bodies or α-synuclein (αSyn) deposition, with later stages correlating with clinical aspects of the disease. In this hypothesis, αSyn deposits begins from the lower brainstem or olfactory bulb, spreads rostrally and reaches to parkinsonism-causing SN and finally to the cerebral cortex. The concept attracted much attention, as it seems to explain the clinical course of PD from prodromal phase to PD with dementia. In this seminar, to understand the mechanism of propagation system of αSyn in PD, DLB and MSA, we organized the distinguished expert in this area. We also discuss with the future treatment against this system of αSyn.
○Takahiko Tokuda (Department of Molecular Pathobiology of Brain Diseases, Kyoto Prefectural University of Mdecine, Japan)
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○Ronald Melki1,2 (1.Centre National de la Recherche Scientifique (CNRS), France, 2.Paris-Saclay Institute of Neurosciences, France)
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○Norihito Uemura, Hodaka Yamakado, Ryosuke Takahashi (Department of Neurology, Kyoto University Graduate School of Medicine, Japan)
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○Yuko Saito (Department of Laboratory Medicine, National Center of Neurology and Psychiatry, Japan)
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○Kenjiro Ono (Department of Neurology, Showa University School of Medicine, Japan)
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○Hideki Mochizuki (Department of Neurology, Osaka University, Japan)
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