第59回日本神経学会学術大会

セッション情報

Neuroscience Frontier Symposium

[NSF-02] Intra- & into-the- brain propagation of α-synuclein: significance for the pathogenesis, progression and therapeutic target of Lewy body diseases

2018年5月24日(木) 15:20 〜 17:20 第2会場 (さっぽろ芸術文化の館3F 瑞雪の間)

座長:望月 秀樹(大阪大学大学院医学系研究科神経内科学), 徳田 隆彦(京都府立医科大学分子脳病態解析学(神経内科学併任))

The Braak’s Staging of PD brain pathology provides useful information about staged distribution of Lewy bodies or α-synuclein (αSyn) deposition, with later stages correlating with clinical aspects of the disease. In this hypothesis, αSyn deposits begins from the lower brainstem or olfactory bulb, spreads rostrally and reaches to parkinsonism-causing SN and finally to the cerebral cortex. The concept attracted much attention, as it seems to explain the clinical course of PD from prodromal phase to PD with dementia. In this seminar, to understand the mechanism of propagation system of αSyn in PD, DLB and MSA, we organized the distinguished expert in this area. We also discuss with the future treatment against this system of αSyn.