Overcome the Challenges of Neurological Disorders

[OC-02] Research frontline of hereditary cerebellar ataxias

Wed. May 23, 2018 1:20 PM - 3:10 PM Room 10 (Royton Sapporo / Highness Hall （2F）)

Chair: Yoshio Ikeda(Department of Neurology, Gunma University Graduate School of Medicine, Japan), Yuji Takahashi(National Center of Neurology and Psychiatry, Japan)

Remarkable diversities exist in the clinical findings and pathogenesis among subtypes of hereditary cerebellar ataxias. Recent research progress on the molecular mechanism of microsatellite repeat expansion disorders such as SCA10, SCA31, FXTAS, and a newly discovered calcium channelopathy SCA42 will be presented and discussed in this session.

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[OC-02-1] SCA31: molecular pathogenesis and role of RNA chaperone

^○Kinya Ishikawa^1,2, Taro Ishiguro², Yoshitaka Nagai³ (1.The Center for Personalized Medicine for Healthy Aging, Tokyo Medical and Dental University, Japan, 2.Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Japan, 3.Department of Neurotherapeutics, Osaka University Graduate School of Medicine, Japan)

[OC-02-2] Repeat associated Non-AUG initiated (RAN) translation in Fragile X-associated Tremor Ataxia Syndrome

^○Peter K. Todd (University of Michigan, USA)

[OC-02-3] SCA42: new calcium channelopathy

^○Hideshi Kawakami, Hiroyuki Morino, Yukiko Matsuda (Department of Epidemiology Research Institute for Radiology & Medicine Hiroshima University, Japan)

[OC-02-4] Molecular Pathology of Spinocerebellar Ataxia 10

^○Tetsuo Ashizawa¹, Karen N. McFarland² (1.Houston Methodist Research Institute, USA, 2.University of Florida, USA)