[EANF-01] Current Findings on Acute Encephalitis via Flavivirus Infection: A form of Zoonosis

[EANF-01-1] Flaviviral infection and the CNS

^○Eng Eong Ooi¹, Jenny G. Low^1,2, Shirin Kalimuddin², Kevin Tan^1,3, Yvonne FZ Chan², Sze Chien Ang², Limin Wijaya² (1.Duke NUS Medical School, Programme in Emerging Infectious Diseases, Singapore, 2.Singapore General Hospital, Department of Infecious Diseases, Singapore, 3.National Neuroscience Institute, Tan Tock Seng Hospital, Singapore)

Professor & Deputy Director:
Emerging Infectious Diseases Programme
Other Affiliations:
Professor, Department of Microbiology & Immunology, National University of Singapore
Professor, Saw Swee Hock School of Public Health, National University of Singapore
Co-director, Viral Research And Experimental Medicine Centre @SingHealth Duke-NUS (ViREMiCS
Research Interest:
The global emergence of epidemic dengue is partly fueled by an incomplete understanding of the determinants of both immunity and pathogenesis. My laboratory aims to address the critical gaps in knowledge in dengue by positioning itself at the interface between clinical epidemiology, virology and immunology. We combine basic virological and virus-host interaction studies with clinical investigations and experimental medicine. Specifically, we are interested in elucidating: (1) how antibodies either protect against or enhance dengue virus infection and (2) the factors that determine the outcome of infection or transmissibility and hence explain its epidemiological phenotype. By elucidating these mechanisms, we hope to contribute to the development of effective vaccines or therapeutics.