[HT-05-1] Tunneling nanotubes allow the spreading of alpha-synuclein fibrils through lysosomal trafficking

Chiara Zurzolo (Unité Trafic Membranaire et Pathogenèse, Institut Pasteur, France)

Autophagy sequesters cytoplasmic material and organelles to lysosomes for degradation. The magnitude of autophagy depends on starvation, oxidative stress, or other noxious conditions, which thereby exerts quality control function that contributes to neurodegeneration and aging. The lysosome was once thought of as a waste bag, a dead-end destination where cellular debris was sent for disposal. However, recent studies have challenged this simple view and found that Lysosomes are not just a sack of digestive enzymes, but rather a signaling/sorting hub related to all of the materials used in the cell. In this symposium, we will invite four speakers with known expertise to share the recently discovered properties of the autophagy-lysosome system in neurological conditions and offer helpful hints on how to develop therapeutic strategies to combat these devastating diseases.

[HT-05-2] Lysosomal dysfunction in Parkinson´s disease and what postmortem brains tell us

Glenda M. Halliday (Brain and Mind Centre and Faculty of Medicine and Health Central Clinical School, University of Sydney, Australia)

Autophagy sequesters cytoplasmic material and organelles to lysosomes for degradation. The magnitude of autophagy depends on starvation, oxidative stress, or other noxious conditions, which thereby exerts quality control function that contributes to neurodegeneration and aging. The lysosome was once thought of as a waste bag, a dead-end destination where cellular debris was sent for disposal. However, recent studies have challenged this simple view and found that Lysosomes are not just a sack of digestive enzymes, but rather a signaling/sorting hub related to all of the materials used in the cell. In this symposium, we will invite four speakers with known expertise to share the recently discovered properties of the autophagy-lysosome system in neurological conditions and offer helpful hints on how to develop therapeutic strategies to combat these devastating diseases.

[HT-05-3] Muscle diseases with autophagic abnormalities

Ichizo Nishino (Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Japan)

Autophagy sequesters cytoplasmic material and organelles to lysosomes for degradation. The magnitude of autophagy depends on starvation, oxidative stress, or other noxious conditions, which thereby exerts quality control function that contributes to neurodegeneration and aging. The lysosome was once thought of as a waste bag, a dead-end destination where cellular debris was sent for disposal. However, recent studies have challenged this simple view and found that Lysosomes are not just a sack of digestive enzymes, but rather a signaling/sorting hub related to all of the materials used in the cell. In this symposium, we will invite four speakers with known expertise to share the recently discovered properties of the autophagy-lysosome system in neurological conditions and offer helpful hints on how to develop therapeutic strategies to combat these devastating diseases.

[HT-05-4] Endo-lysosomal trafficking defect as a unifying concept of neurodegenerative diseases

Takafumi Hasegawa (Division of Neurology, Department of Neuroscience & Sensory Organs, Tohoku University Graduate School of Medicine, Japan)

Autophagy sequesters cytoplasmic material and organelles to lysosomes for degradation. The magnitude of autophagy depends on starvation, oxidative stress, or other noxious conditions, which thereby exerts quality control function that contributes to neurodegeneration and aging. The lysosome was once thought of as a waste bag, a dead-end destination where cellular debris was sent for disposal. However, recent studies have challenged this simple view and found that Lysosomes are not just a sack of digestive enzymes, but rather a signaling/sorting hub related to all of the materials used in the cell. In this symposium, we will invite four speakers with known expertise to share the recently discovered properties of the autophagy-lysosome system in neurological conditions and offer helpful hints on how to develop therapeutic strategies to combat these devastating diseases.