60th Annual Meeting of the Japanese Society of Neurology

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Oral Session

[O-05] Neuroimmunology (Basic research)

Wed. May 22, 2019 3:35 PM - 5:05 PM Room 8 (Osaka International Convention Center 10F Conference Room 1004)

Chair:Takashi Yamamura(Department of Immunology, National Institute of Neuroscience) Commentator:Qiu Wei(The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong Province)

[O-05-1] Gray but not white matter astroglia-specific connexin 43 ablation ameliorates neuroinflammation

Hayato Une1,2, Satoshi Nagata1, Ryo Yamasaki1, Hiroo Yamaguchi1, Koji Shinoda1, Katsuhisa Masaki1, Magdalena Götz3, Jun-ichi Kira1 (1.Department of Neurology, Neurological institute, Graduate School of Medical Sciences, Kyushu University, Japan, 2.Department of Neurology, Iizuka Hospital, Japan, 3.Physiological Genomics, Biomedical Center, Ludwig-Maximilians University Munich, Munich, Germany)

[O-05-2] Disease-specific TCRs recognize CMV in Japanese MS with HLA-DRB1*04:05; a novel approach with GLIPH

Fumie Hayashi1, Noriko Isobe2, Jacob Glanville3, Yuri Nakamura2, Takuya Matsushita1, Jun-ichi Kira1 (1.Department of Neurology, Graduate School of Medical Sciences, Kyushu University, Japan, 2.Department of Neurological Therapeutics, Graduate School of Medical Sciences, Kyushu University, 3.Computational and Systems Immunology Program, Stanford University School of Medicine)

[O-05-3] Gut microbiota dysbiosis leading to the development and progression of multiple sclerosis

Daiki Takewaki1,2, Wakiro Sato1,2, Wataru Suda3,4,5, Lena Takayasu3,4, Naveen Kumar3, Sachiko Miyake7, Masahira Hattori3,4,6, Takashi Yamamura1,2 (1.Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Japan, 2.Multiple Sclerosis Center, National Center of Neurology and Psychiatry, Japan, 3.Laboratory for microbiome science, RIKEN, Japan, 4.School of International Health, Graduate School of Medicine, The University of Tokyo, Japan, 5.Department of Microbiology and Immunology, School of Medicine, Keio University, Japan, 6.Department of Advanced Science and Engineering, Faculty of Science and Engineering, Waseda University, Japan, 7.Department of Immunology, School of Medicine, Juntendo University, Japan)

[O-05-4] Effect of immunogenetic background on JCV infection in Japanese patients with multiple sclerosis

Yuri Nakamura1, Mitsuru Watanabe1, Noriko Isobe2, Ayako Sakoda1, Takuya Matsushita1, Masami Tanaka3,4, Jun-ichi Kira1 (1.Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Japan, 2.Department of Neurological Therapeutics, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3.Kyoto MS Center, Kyoto Min-Iren-Chuo Hospital, 4.Department of Neurology, Kaikoukai Josai Hospital)

[O-05-5] T cell response to myelin oligodendrocyte glycoprotein (MOG) in patients with anti-MOG antibody

Hirohiko Ono1, Tatsuro Misu2, Yoshiki Takai1, Shuhei Nishiyama1, Hiroshi Kuroda1, Toshiyuki Takahashi3, Ichiro Nakashima4, Kazuo Fujihara5, Masashi Aoki1 (1.Department of Neurology, Tohoku University School of Medicine, Japan, 2.Department of Multiple Sclerosis Therapeutics, Tohoku University Graduate School of Medicine, 3.Department of Neurology, Yonezawa National Hospital, 4.Department of Neurology, Tohoku Medical and Pharmaceutical University, 5.Department of Multiple Sclerosis Therapeutics, Fukushima Medical University School of Medicine)