[S-16-1] THE HISTORY AND EVOLUTION OF NEUROMYELITIS OPTICA SPECTRUM DISORDERS

Brian G. Weinshenker (Dept of Neurology, Mayo Clinic Rochester, USA)

Neuromyelitis optica (NMO) was originally proposed by Devic. The concept of NMO spectrum disorder (NMOSD) had been proposed after the discovery of anti-aquaporin 4(AQP4) antibody, shedding light on the anti-AQP4 antibody positive cases without optic neuritis or myelitis, or seronegative opticospinal cases, which is distinct from classical multiple sclerosis (MS). However, it is now revealed that there are similar cases with bilateral optic neuritis, transverse myelitis or acute disseminated encephalomyelitis associated only with anti-myelin oligodendrocyte glycoprotein (MOG) antibody, which in these groups some patients had similar features to MS clinically or pathologically. While considering the historical concept of NMO, we are now in front of the spreading of disease concept in NMOSD. We will discuss how these diseases should be grouped and treated from the viewpoints of clinical and pathological studies.

[S-16-2] From the viewpoint of pathological study in MS

Izumi Kawachi (Dept. of Neurology, Brain Research Institute, Niigata University, Japan)

Neuromyelitis optica (NMO) was originally proposed by Devic. The concept of NMO spectrum disorder (NMOSD) had been proposed after the discovery of anti-aquaporin 4(AQP4) antibody, shedding light on the anti-AQP4 antibody positive cases without optic neuritis or myelitis, or seronegative opticospinal cases, which is distinct from classical multiple sclerosis (MS). However, it is now revealed that there are similar cases with bilateral optic neuritis, transverse myelitis or acute disseminated encephalomyelitis associated only with anti-myelin oligodendrocyte glycoprotein (MOG) antibody, which in these groups some patients had similar features to MS clinically or pathologically. While considering the historical concept of NMO, we are now in front of the spreading of disease concept in NMOSD. We will discuss how these diseases should be grouped and treated from the viewpoints of clinical and pathological studies.

[S-16-3] From the viewpoint of clinical and epidemiological MS study in Japan

Katsuichi Miyamoto (Department of Neurology, Kindai University School of Medicine, Japan)

Neuromyelitis optica (NMO) was originally proposed by Devic. The concept of NMO spectrum disorder (NMOSD) had been proposed after the discovery of anti-aquaporin 4(AQP4) antibody, shedding light on the anti-AQP4 antibody positive cases without optic neuritis or myelitis, or seronegative opticospinal cases, which is distinct from classical multiple sclerosis (MS). However, it is now revealed that there are similar cases with bilateral optic neuritis, transverse myelitis or acute disseminated encephalomyelitis associated only with anti-myelin oligodendrocyte glycoprotein (MOG) antibody, which in these groups some patients had similar features to MS clinically or pathologically. While considering the historical concept of NMO, we are now in front of the spreading of disease concept in NMOSD. We will discuss how these diseases should be grouped and treated from the viewpoints of clinical and pathological studies.

[S-16-4] Neuromyelitis optica : Taiwanese exprience

Jen Jen Su (Department of Neurology, National Taiwan University hospital, Taiwan)

Neuromyelitis optica (NMO) was originally proposed by Devic. The concept of NMO spectrum disorder (NMOSD) had been proposed after the discovery of anti-aquaporin 4(AQP4) antibody, shedding light on the anti-AQP4 antibody positive cases without optic neuritis or myelitis, or seronegative opticospinal cases, which is distinct from classical multiple sclerosis (MS). However, it is now revealed that there are similar cases with bilateral optic neuritis, transverse myelitis or acute disseminated encephalomyelitis associated only with anti-myelin oligodendrocyte glycoprotein (MOG) antibody, which in these groups some patients had similar features to MS clinically or pathologically. While considering the historical concept of NMO, we are now in front of the spreading of disease concept in NMOSD. We will discuss how these diseases should be grouped and treated from the viewpoints of clinical and pathological studies.

[S-16-5] Insights into the concept and pathology of NMOSD and MS in association with AQP4 and MOG antibodies

Tatsuro Misu (Department of Neurology, Tohoku University, Japan)

Neuromyelitis optica (NMO) was originally proposed by Devic. The concept of NMO spectrum disorder (NMOSD) had been proposed after the discovery of anti-aquaporin 4(AQP4) antibody, shedding light on the anti-AQP4 antibody positive cases without optic neuritis or myelitis, or seronegative opticospinal cases, which is distinct from classical multiple sclerosis (MS). However, it is now revealed that there are similar cases with bilateral optic neuritis, transverse myelitis or acute disseminated encephalomyelitis associated only with anti-myelin oligodendrocyte glycoprotein (MOG) antibody, which in these groups some patients had similar features to MS clinically or pathologically. While considering the historical concept of NMO, we are now in front of the spreading of disease concept in NMOSD. We will discuss how these diseases should be grouped and treated from the viewpoints of clinical and pathological studies.

Session information