60th Annual Meeting of the Japanese Society of Neurology

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Symposium

[S-35] Progressive multifocal leukoencephalopathy in the era of disease-modifying therapies

Sat. May 25, 2019 8:00 AM - 10:00 AM Room 11 (Osaka International Convention Center 12F Conference Room 1202)

Chair:Motohiro Yukitake(Kouhoukai Takagi Hospital, Division of Neurology, Japan), Nobuo Sanjo(Department of Neurology and Neurological Science, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Japan)

Progressive multifocal leukoencephalopathy (PML) is a rare and severe demyelinating disease of the white matter in the central nervous system caused by JC virus. Multiple sclerosis (MS) treating with disease-modifying therapies (DMT) is newly coming underlying disease of PML. In MS, DMT have recently been shown to reduce the frequency and severity of clinical relapse. Although freedom from disease activity has become the primary aim of the treatment of MS, these DMT increase the risk of PML.
In this symposium, latest information of DMT induced PML, characteristics of MRI in DMT induced PML, development of JC virus DNA detection in the cerebrospinal fluid, and newly aspects of PML will be presented.

[S-35-1] Progressive multifocal leukoencephalopathy in the era of disease-modifying therapies

David B. Clifford (Washington University in St Louis, USA)

Progressive multifocal leukoencephalopathy (PML) is a rare and severe demyelinating disease of the white matter in the central nervous system caused by JC virus. Multiple sclerosis (MS) treating with disease-modifying therapies (DMT) is newly coming underlying disease of PML. In MS, DMT have recently been shown to reduce the frequency and severity of clinical relapse. Although freedom from disease activity has become the primary aim of the treatment of MS, these DMT increase the risk of PML.
In this symposium, latest information of DMT induced PML, characteristics of MRI in DMT induced PML, development of JC virus DNA detection in the cerebrospinal fluid, and newly aspects of PML will be presented.

[S-35-2] A controlled inflammation and a regulatory immune system are associated with better prognosis of PML

Nobuo Sanjo1, Yukiko Shishido-hara2, Yurie Nose1, Takanori Yokota1 (1.Department of Neurology and Neurological Science, Tokyo Medical and Dental University, Japan, 2.Department of Anatomic Pathology, Tokyo Medical University)

Progressive multifocal leukoencephalopathy (PML) is a rare and severe demyelinating disease of the white matter in the central nervous system caused by JC virus. Multiple sclerosis (MS) treating with disease-modifying therapies (DMT) is newly coming underlying disease of PML. In MS, DMT have recently been shown to reduce the frequency and severity of clinical relapse. Although freedom from disease activity has become the primary aim of the treatment of MS, these DMT increase the risk of PML.
In this symposium, latest information of DMT induced PML, characteristics of MRI in DMT induced PML, development of JC virus DNA detection in the cerebrospinal fluid, and newly aspects of PML will be presented.

[S-35-3] Characteristics of MR imaging on progressive multifocal leukoencephalopathy and recent advance

Masafumi Harada, Takashi Abe, Yuko Sakamoto (Department of Radiology, Tokushima University, Japan)

Progressive multifocal leukoencephalopathy (PML) is a rare and severe demyelinating disease of the white matter in the central nervous system caused by JC virus. Multiple sclerosis (MS) treating with disease-modifying therapies (DMT) is newly coming underlying disease of PML. In MS, DMT have recently been shown to reduce the frequency and severity of clinical relapse. Although freedom from disease activity has become the primary aim of the treatment of MS, these DMT increase the risk of PML.
In this symposium, latest information of DMT induced PML, characteristics of MRI in DMT induced PML, development of JC virus DNA detection in the cerebrospinal fluid, and newly aspects of PML will be presented.

[S-35-4] JC virus detection methods in the cerebrospinal fluid for PML-diagnosis; past, present, and future

Masayuki Saijo, Kazuo Nakamichi (Department of Virology 1, National Institute of Infectious Diseases, Japan)

Progressive multifocal leukoencephalopathy (PML) is a rare and severe demyelinating disease of the white matter in the central nervous system caused by JC virus. Multiple sclerosis (MS) treating with disease-modifying therapies (DMT) is newly coming underlying disease of PML. In MS, DMT have recently been shown to reduce the frequency and severity of clinical relapse. Although freedom from disease activity has become the primary aim of the treatment of MS, these DMT increase the risk of PML.
In this symposium, latest information of DMT induced PML, characteristics of MRI in DMT induced PML, development of JC virus DNA detection in the cerebrospinal fluid, and newly aspects of PML will be presented.

[S-35-5] Genetic backgrounds of Japanese MS and JC virus antibody

Noriko Isobe (Department of Neurological Therapeutics, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Japan)

Progressive multifocal leukoencephalopathy (PML) is a rare and severe demyelinating disease of the white matter in the central nervous system caused by JC virus. Multiple sclerosis (MS) treating with disease-modifying therapies (DMT) is newly coming underlying disease of PML. In MS, DMT have recently been shown to reduce the frequency and severity of clinical relapse. Although freedom from disease activity has become the primary aim of the treatment of MS, these DMT increase the risk of PML.
In this symposium, latest information of DMT induced PML, characteristics of MRI in DMT induced PML, development of JC virus DNA detection in the cerebrospinal fluid, and newly aspects of PML will be presented.