[HT-03] Newly Emerging Concepts on PSP and CBD

[HT-03-1] Overview of clinical aspects of tauopathies including PSP and CBD

Zbgniew Wszolek (Mayo Clinic Florida, USA)

Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are neuropathologically characterized by accumulation of phosphorylated 4-repeat tau in brain. Clinical diagnosis of PSP and CBD is challenging because correlation between clinical phenotypes and underlying neuropathological findings is often inconsistent. Recently, new criteria for PSP diagnosis have been proposed by the Movement Disorder Society-endorsed Study Group. In addition, genetic analysis and molecular imaging study now provide useful information to make accurate diagnosis of PSP and CBD. With disease-modifying therapies being developed, accurate diagnosis of patients in early-stage disease is becoming more urgent. In this symposium, we will discuss how we can make diagnosis of PSP and CBD efficiently on the basis of recent progress of clinical, genetic, neuropathological and neuroimaging analyses.

Dr. Wszolek is a Consultant at Mayo Clinic and a Professor of Neurology in the Mayo Clinic College of Medicine. He graduated from the Silesian Medical University in Katowice, Poland. His postgraduate training included neurology, clinical neurophysiology, movement disorders, and positron emission tomography residencies and fellowships in Poland, the United States, and Canada. His scientific interests are in the field of clinical genetics of neurodegenerative conditions. He has been instrumental in the discovery of several genes in which the mutations produce the clinical signs of parkinsonism, dementia, dystonia, ataxia, and others. He has published extensively in peer-reviewed journals (500+ publications posted on PubMed.gov). He is a Fellow Member of the American Academy of Neurology and the American Neurological Association. He is a Honorary Member of the Polish and Japanese Societies of Neurology, and a Distinguished Fellow of the Collegium of Eminent Scientists of Polish Origin and Ancestry of the Kosciuszko Foundation. He was a founding officer and former Treasurer and Councilor of the International Association of Parkinsonism and Related Disorders. He is a former Co-Editor-in-Chief of Parkinsonism and Related Disorders and Associate Editor of European Journal of Neurology. He currently serves as Co-Editor-in-Chief of Polish Journal of Neurology and Neurosurgery.