[S-17] Mechanisms of novel pathogenic autoantibodies in chronic immune-mediated neuropathies

[S-17-1] Ultrastructure of CIDP: A role of autoantibodies to nodal or paranodal proteins in the pathogenesis

Haruki Koike (Department of Neurology, Nagoya University Graduate School of Medicine, Japan)

Newly discovered autoantibodies that react with the specific sites of peripheral nerves produces unique clinical manifestations and laboratory findings, such as neuropathic pain, autonomic symptoms, nerve hypertrophy, and axo-glial detachment. These manifestations might be originated from antibody-antigen interaction at specific sites such as nodes of Ranvier, paranodes, posterior ganglion small neurons, and autonomic ganglia. This symposium encompasses anti-neurofascin155 and -contactin1 antibodies targeting the paranodes, anti-plexinD1 antibody targeting the primary pain-conducting neurons, and anti-ganglionic acetylcholine receptor antibody targeting the autonomic ganglia. These autoantibodies could be not only diagnostic biomarkers but also pathogenic. The purpose of this symposium is to deepen the knowledge about the mechanism and cascade of events leading to the specific manifestations of neuropathy by each autoantibody.

Apr 2002 - Mar 2008, Staff physician, Nagoya University Graduate School of Medicine
Apr 2008 - Sep 2008, Visiting physician, Nagoya University Graduate School of Medicine
Oct 2008 - Mar 2009, Research Assistant, Nagoya University Graduate School of Medicine
Apr 2009 - Jan 2013, Research Associate, Nagoya University Graduate School of Medicine
Feb 2013 - Dec 2015, Lecturer, Nagoya University Graduate School of Medicine
Jan 2016 - Current, Associate Professor, Nagoya University Graduate School of Medicine