[S-17] Mechanisms of novel pathogenic autoantibodies in chronic immune-mediated neuropathies

[S-17-2] Autoantibodies against nodes of Ranvier and paranodes in CIDP

Hidenori Ogata¹, Ryo Yamasaki², Jun-ichi Kira² (1.Department of neurology, Kyushu University Hospital, Japan, 2.Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University)

Newly discovered autoantibodies that react with the specific sites of peripheral nerves produces unique clinical manifestations and laboratory findings, such as neuropathic pain, autonomic symptoms, nerve hypertrophy, and axo-glial detachment. These manifestations might be originated from antibody-antigen interaction at specific sites such as nodes of Ranvier, paranodes, posterior ganglion small neurons, and autonomic ganglia. This symposium encompasses anti-neurofascin155 and -contactin1 antibodies targeting the paranodes, anti-plexinD1 antibody targeting the primary pain-conducting neurons, and anti-ganglionic acetylcholine receptor antibody targeting the autonomic ganglia. These autoantibodies could be not only diagnostic biomarkers but also pathogenic. The purpose of this symposium is to deepen the knowledge about the mechanism and cascade of events leading to the specific manifestations of neuropathy by each autoantibody.

Mar. 2006 MD, Kanazawa University
Mar. 2016 PhD, Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University
Apr. 2006 - Mar. 2009 Resident, Izuka Hospital
Mar. 2009 - Jul. 2009 Neurological Resident, Kyushu University Hospital
Aug. 2009 - Sep. 2009 Neurological Resident, National Hospital Organization Omuta Hospital
Oct. 2009 - Mar. 2010 Neurological Resident, Kyushu University Hospital
Apr. 2010 - Mar. 2012 Medical staff, Matsuyama Red Cross Hospital
Apr. 2016 - Dec. 2016 Medical staff, Kyushu University Hospital
Jan. 2017 - Assistant Professor, Kyushu University Hospital