[S-17] Mechanisms of novel pathogenic autoantibodies in chronic immune-mediated neuropathies

[S-17-3] The ganglionic AChR antibodies in autoimmune autonomic ganglionopathy

Shunya Nakane^1,2, Yukio Ando¹ (1.Department of Neurology, Kumamoto University Hospital, Japan, 2.Department of Molecular Neurology and Therapeutics, Kumamoto University Hospital, Japan)

Newly discovered autoantibodies that react with the specific sites of peripheral nerves produces unique clinical manifestations and laboratory findings, such as neuropathic pain, autonomic symptoms, nerve hypertrophy, and axo-glial detachment. These manifestations might be originated from antibody-antigen interaction at specific sites such as nodes of Ranvier, paranodes, posterior ganglion small neurons, and autonomic ganglia. This symposium encompasses anti-neurofascin155 and -contactin1 antibodies targeting the paranodes, anti-plexinD1 antibody targeting the primary pain-conducting neurons, and anti-ganglionic acetylcholine receptor antibody targeting the autonomic ganglia. These autoantibodies could be not only diagnostic biomarkers but also pathogenic. The purpose of this symposium is to deepen the knowledge about the mechanism and cascade of events leading to the specific manifestations of neuropathy by each autoantibody.

Specially Appointed Professor, Kumamoto University Hospital
Education
2000: Ph. D. Graduate School of Biomedical Sciences, Nagasaki University
1994: M. D. Kagawa University School of Medicine
Employment
2018-: Department of Molecular Neurology and Therapeutics, Kumamoto University Hospital
2015-2018: Department of Neurology, Graduate School of Medical Sciences, Kumamoto University
2008-2015: Department of Neurology and Clinical Research, Nagasaki Kawatana Medical Center
2004-2008: Department of Clinical Neuroscience,Tokushima University Graduate School
2001-2004: Department of Neurology and Immunology, Mayo Clinic Rochester
2000-2001: Department of Neurology, Nagasaki Kawatana Hospital
1994-2000: First Department of Internal Medicine, Nagasaki University
Licence and Certification
National Board of Medicine, Registration No. 365667: Japanese Board of Neurology, Registration No. 3082
Awards
Award of the 26th Annual Meeting of Japanese Society for Neuroimmunology, 2014